LSU Orthopaedics Awarded Two CDMRP Grants

We are excited to announce LSU Orthopaedics has been awarded two grants from the CDMRP. The CDMRP (Congressionally Directed Medical Research Programs) began in 1992 via a Congressional appropriation to foster novel approaches to biomedical research in response to the expressed needs of its stakeholders-the American public, the military, and Congress. In 2021, they were able to award $30,000,000 to research in the Peer Reviewed Orthopaedic Program. 

Our project, "Intraosseous Antibiotic for Point of Care Wound Prophylaxis," was funded by the FY21 Peer Reviewed Orthopaedic Program Applied Research Award. This is the second Applied Research Award our lab has received in two consecutive funding cycles.  This study will compare microbial wound burden in a composite tissue porcine contaminated wound model following IV versus IO antibiotic delivery with and without tourniquet application.  The award is for $723,100 including $224,161 indirect costs to LSU. Dr. Jennifer Simkin is an AI on this exciting project.

Our second project, "Intramedullary Calcium Sulfate Antibiotic Depot for Prevention of Open Fracture Related Infection: A Randomized Clinical Trial," was funded by the FY21 Peer Reviewed Orthopaedic Program Clinical Trial Award Program.  This study will compare fracture related infection frequency following locally delivered intramedullary antibiotics at the time of definitive fracture fixation compared to standard of care.  The award is for $2,242,983 including $189,423 indirect costs to LSU.  We will be subawarding funds to our outstanding collaborators at Atrium Health to serve as the trial coordinating center.