School of Medicine

• Podocyte cell-specific Npr1 is required for blood pressure and renal homeostasis in male and female mice: role of sex-specific differences.
  Ramasamy C, Neelamegam K, Ramachandran S, Xia H, Kapusta DR, Danesh FR, Pandey KN.Physiol Genomics. 2024 Oct 1;56(10):672-690. doi: 10.1152/physiolgenomics.00137.2023. Epub 2024 Aug 5.PMID: 39101921
• Epigenetic mechanisms differentially regulate blood pressure and renal dysfunction in male and female Npr1 haplotype mice.
  Kumar P, Neelamegam K, Ramasamy C, Samivel R, Xia H, Kapusta DR, Pandey KN.FASEB J. 2024 Aug 15;38(15):e23858. doi: 10.1096/fj.202400714R.PMID: 39109516 
• Comparison Between Two Divergent Diets, Mediterranean and Western, on Gut Microbiota and Cognitive Function in Young Sprague Dawley Rats.Solch-Ottaiano RJ, Engler-Chiurazzi EB, Harper C, Wasson S, Ogbonna S, Ouvrier B, Wang H, Prats M, McDonald K, Biose IJ, Rowe LA, Jones M, Steele C, Bix G, Maraganore DM.Gut Microbes Rep. 2024;1(1):1-21. doi: 10.1080/29933935.2024.2439490. Epub 2024 Dec 18.PMID: 39916748
• Effect of Diminazene Aceturate, an ACE2 activator, on platelet CD40L signaling induced glial activation in rat model of hypertension. Tiwari P, Elgazzaz M, Lazartigues E, Hanif K.Int Immunopharmacol. 2024 Sep 30;139:112654. doi: 10.1016/j.intimp.2024.112654. Epub 2024 Jul 11.PMID: 38996777
• Myeloid Deficiency of Heparan Sulfate 6-O-Endosulfatases Impairs Bone Marrow Hematopoiesis. Whitehead AK, Wang Z, Boustany RJ, Vivès RR, Lazartigues E, Liu J, Siggins RW, Yue X.Matrix Biol. 2024 Oct 3:S0945-053X(24)00123-9. doi: 10.1016/j.matbio.2024.10.002. Online ahead of print.PMID: 39368561
•  Cardiovascular dysfunction induced by combined exposure to nicotine inhalation and high-fat diet. Whitehead AK, Li Z, LaPenna KB, Abbes N, Sharp TE, Lefer DJ, Lazartigues E, Yue X.Am J Physiol Heart Circ Physiol. 2024 Jan 1;326(1):H278-H290. doi: 10.1152/ajpheart.00474.2023. Epub 2023 Dec 1.PMID: 38038717
• Maternal Western diet programs cardiometabolic dysfunction and hypothalamic inflammation via epigenetic mechanisms predominantly in the male offspring. Elgazzaz M, Berdasco C, Garai J, Baddoo M, Lu S, Daoud H, Zabaleta J, Mauvais-Jarvis F, Lazartigues E.Mol Metab. 2024 Feb;80:101864. doi: 10.1016/j.molmet.2023.101864. Epub 2023 Dec 28.PMID: 38159883 
• Stable, neuron-specific gene expression in the mouse brain. Ahmed O, Ekumi KM, Nardi FV, Maisumu G, Moussawi K, Lazartigues ED, Liang B, Yakoub AM.J Biol Eng. 2024 Jan 16;18(1):8. doi: 10.1186/s13036-023-00400-5.PMID: 38229168
• IF1 Promotes Cellular Proliferation and Inhibits Oxidative Phosphorylation in Mouse Embryonic Fibroblasts under Normoxia and Hypoxia.  Lauterboeck L, Kang SW, White D 3rd, Bao R, Mobasheran P, Yang Q.Cells. 2024 Mar 21;13(6):551. doi: 10.3390/cells13060551.PMID: 38534395 
• Angiotensin-Converting Enzyme 2 Posttranslational Modifications and Implications for Hypertension and SARS-CoV-2: 2023 Lewis K. Dahl Memorial Lecture.Elgazzaz M, Filipeanu CM, Lazartigues E.Hypertension. 2024 Jul;81(7):1438-1449. doi: 10.1161/HYPERTENSIONAHA.124.22067. Epub 2024 Apr 3.PMID: 38567498 
•  Sleep apnea and ischemic stroke- a perspective for translational preclinical modelling. Biose IJ, Bakare AB, Wang H, Gressett TE, Bix GJ.Sleep Med Rev. 2024 Jun;75:101929. doi: 10.1016/j.smrv.2024.101929. Epub 2024 Apr 1.PMID: 38581800 
•  Upregulation of inflammatory genes and pathways links obesity to severe COVID-19.Currey J, Ellsworth C, Khatun MS, Wang C, Chen Z, Liu S, Midkiff C, Xiao M, Ren M, Liu F, Elgazzaz M, Fox S, Maness NJ, Rappaport J, Lazartigues E, Blair R, Kolls JK, Mauvais-Jarvis F, Qin X.Biochim Biophys Acta Mol Basis Dis. 2024 Oct;1870(7):167322. doi: 10.1016/j.bbadis.2024.167322. Epub 2024 Jun 26.PMID: 38942338
• Adjunctive therapy with an oral H₂S donor provides additional therapeutic benefit beyond SGLT2 inhibition in cardiometabolic heart failure with preserved ejection fraction. Doiron JE, Xia H, Yu X, Nevins AR, LaPenna KB, Sharp TE 3rd, Goodchild TT, Allerton TD, Elgazzaz M, Lazartigues E, Shah SJ, Li Z, Lefer DJ.Br J Pharmacol. 2024 Jul 9. doi: 10.1111/bph.16493. Online ahead of print.PMID: 38982742

• Hydrogen Sulfide Modulates Endothelial-Mesenchymal Transition in Heart Failure.
  Li Z, Xia H, Sharp TE 3rd, LaPenna KB, Katsouda A, Elrod JW, Pfeilschifter J, Beck KF, Xu S, Xian M, Goodchild TT, Papapetropoulos A, Lefer DJ.Circ Res. 2023 Jan 20;132(2):154-166. doi: 10.1161/CIRCRESAHA.122.321326. Epub 2022 Dec 28.PMID: 36575984
• Dr. Eric Lazartigues was selected to present the 2023 Lewis K. Dahl Memorial Lecture at the American Heart Association Hypertension conference.
• New publication entitled “New approaches targeting the renin-angiotensin system: inhibition of brain aminopeptidase A, ACE2 ubiquitination, and angiotensinogen” published in Canadian Journal of Cardiology (6/2023).
• New collaborative paper entitled “Nedd4-2 upregulation is associated with ACE2 ubiquitination in hypertension” published in Cardiovascular Research (5/2023).

• Mohammed M, Ogunlade B, Elgazzaz M, Berdasco C, Lakkappa N, Ghita I, Guidry JJ, Sriramula S, Xu J, Restivo L, Mendiola Plá MA, Bowles DE, Beyer AM, Yue X, Lazartigues E, Filipeanu CM. Nedd4-2 up-regulation is associated with ACE2 ubiquitination in hypertension. Cardiovasc Res. 2023 Sep 5;119(11):2130-2141. doi: 10.1093/cvr/cvad070. PubMed PMID: 37161607; PubMed Central PMCID: PMC10478751.
• Whitehead AK, Li Z, LaPenna KB, Abbes N, Sharp TE, Lefer DJ, Lazartigues E, Yue X. Cardiovascular dysfunction induced by combined exposure to nicotine inhalation and high-fat diet. Am J Physiol Heart Circ Physiol. 2024 Jan 1;326(1):H278-H290. doi: 10.1152/ajpheart.00474.2023. Epub 2023 Dec 1. PubMed PMID: 38038717; PubMed Central PMCID: PMC11219050.
• Nedd4-2 up-regulation is associated with ACE2 ubiquitination in hypertension.
  Mohammed M, Ogunlade B, Elgazzaz M, Berdasco C, Lakkappa N, Ghita I, Guidry JJ, Sriramula S, Xu J, Restivo L, Mendiola Plá MA, Bowles DE, Beyer AM, Yue X, Lazartigues E, Filipeanu CM.Cardiovasc Res. 2023 Sep 5;119(11):2130-2141. doi: 10.1093/cvr/cvad070.