School of Medicine

• Sex-Specific Exosome Cargo Reveals Potential New Mechanisms of Salt-Sensitive HypertensionTarhriz V, Xia H, Patel A, Eivazi M, Scarborough A, Miao K, Mir H, Abkhooie L, Mauvais-Jarvis F, Lazartigues E. Sex-Specific Exosome Cargo Reveals Potential New Mechanisms of Salt-Sensitive Hypertension. Hypertension. 2025 Dec 15. doi: 10.1161/HYPERTENSIONAHA.125.25949. Epub ahead of print. PMID: 41392884.
• Hypertensive remodelling: when bigger body means bigger problemsLazartigues E. Hypertensive remodelling: when bigger body means bigger problems. Cardiovasc Res. 2025 Dec 9;121(15):2281-2282. doi: 10.1093/cvr/cvaf245. PMID: 41250849; PMCID: PMC12687875.
• Estrogen and obesity synergistically suppress protein S via HIF1α, enhancing thrombosis potentialMohammad MA, Kumar N, Ghosh S, Paysse A, Leonardi C, Pilli V, Duhaylungsod ML, Lazartigues E, Polania-Villanueva DC, Nouman S, Barrios LA, Chattopadhyay R, Yasmin R, Guilbeau A, Kumar M, Nguyen T, Zabaleta J, Li L, Del Valle L, Barbier MT, Majumder S, Mosnier LO, Majumder R. Estrogen and obesity synergistically suppress protein S via HIF1α, enhancing thrombosis potential. J Clin Invest. 2025 Nov 17;135(22):e193976. doi: 10.1172/JCI193976. PMID: 41243971; PMCID: PMC12618064.
• Acute Optogenetic Stimulation of Serotonin Neurons Reduces Cell Proliferation in the Dentate Gyrus of MiceAraragi N, Petermann M, Suzuki M, Larkum M, Mosienko V, Bader M, Alenina N, Klempin F. Acute Optogenetic Stimulation of Serotonin Neurons Reduces Cell Proliferation in the Dentate Gyrus of Mice. ACS Chem Neurosci. 2025 Mar 5;16(5):781-789. doi: 10.1021/acschemneuro.4c00771. Epub 2025 Feb 12. PMID: 39937171; PMCID: PMC11887043.
• Diurnal behavioral outcomes and BBB integrity in adult male SHR and WKY rats.Shrivastava P, Biose OD, Dahal R, Jwayyed A, Raji RA, Xia H, Lazartigues E, Biose IJ. Diurnal behavioral outcomes and BBB integrity in adult male SHR and WKY rats. Sci Rep. 2025 Nov 24;15(1):41637. doi: 10.1038/s41598-025-25585-1. PMID: 41285975; PMCID: PMC12644676.
• Deep learning-driven proteomics analysis for gene annotation in the renin-angiotensin system. Eivazi M, Hosseini K, Alipanahi S, Xia H, Restivo L, Patel A, Gozali M, Ebrahimi T, Scarborough A, Tarhriz V, Lazartigues E. Eur J Pharmacol. 2025 Sep 2;1006:178119. doi: 10.1016/j.ejphar.2025.178119. Online ahead of print. PMID: 40907688
• Targeting Kinin B1R Attenuates Hypertension Through AT1R-Dependent Mechanisms. Theobald D, Bessetti RN, Feng Earley Y, Lazartigues E, Litwa K, Sriramula S. Circ Res. 2025 Sep 12;137(7):950-966. doi: 10.1161/CIRCRESAHA.125.326648. Epub 2025 Aug 20. PMID: 40832695
• ADAM17 Supports Disinhibition of Pre-sympathetic Glutamatergic Neurons Through Microglial Chemotaxis. Wang J, Qiu Z, Han Y, Wu H, Yuan M, Liu Y, Wang H, Yuan S, Gao D, Sun L, Chen X, Lazartigues E, Li F, Yang R, Xu J. Neurosci Bull. 2025 Aug 4. doi: 10.1007/s12264-025-01471-8. Online ahead of print. PMID: 40758224.
• CircRNA-Based AntimiR Therapy: A Novel Approach to Hypertension Treatment. Tarhriz V., Hosseini K., Abkhooie L., Lazartigues E. Noncoding RNA Res. 2025. https://doi.org/10.1016/j.ncrna.2025.05.001
• Molecular Dissection of the Role of ACE2 in Glucose Homeostasis. Chhabra KH, Shoemaker R, Herath CB, Thomas MC, Filipeanu CM, Lazartigues E. Physiol Rev. 2025 Feb 7. doi: 10.1152/physrev.00027.2024. Online ahead of print. PMID: 3991887. Listen to this article’s corresponding podcast here.
• UBR1 Promotes Sex-Dependent ACE2 Ubiquitination in Hypertension. Elgazzaz M, Lakkappa N, Berdasco C, Mohan UP, Nuzzo A, Restivo L, Martinez A, Scarborough A, Guidry JJ, Sriramula S, Xu J, Daoud H, Mendiola Plá MA, Bowles DE, Beyer AM, Mauvais-Jarvis F, Yue X, Filipeanu CM, Lazartigues E. Hypertension. 2025 Jan;82(1):84-95. doi: 10.1161/HYPERTENSIONAHA.124.23196. PMID: 39601126