Education

2023- AHA Fellowship
Tulane University, New Orleans, LA

2019- Ph.D. Neuroscience
University of Glasgow, Scotland, United Kingdom.

2012- M.Sc. Anatomy
University of Lagos, Lagos, Nigeria.

2010- B.Sc. Anatomy
University of Benin, Benin City, Nigeria.

Research

The central objective of my research endeavor is to increase knowledge on the impact of gut-derived metabolites on aging-related and post-stroke cognition as well as the progression of heart failure with preserved ejection fraction (HFpEF). Emerging data demonstrate the importance of targeting the gut microbiome in ameliorating cognitive impairments and aging-related disease progression. Using preclinical models and clinical samples, my laboratory is pursuing novel and translational approaches to mitigate the progression of cognitive decline and HFpEF whilst gaining population and mechanistic insights for therapeutic strategies.

 

Areas of Expertise

Modelling ischemic and hemorrhagic stroke

Aging-related comorbidities

Rodent functional assessments

Neuroimaging

Current research Opportunities

Graduate student positions are available immediately. Contact Dr. Ifechukwude Biose (ibiose@lsuhsc.edu)

Publications

My Bibliography - NCBI (nih.gov)

https://www.ncbi.nlm.nih.gov/myncbi/ifechukwude%20joachim.biose.1/bibliography/public/

Biose IJ, Chastain W, Solch-Ottaiano RJ, Grayson V, Wang H, Banerjee S and Bix GJ. Effect of exercise on experimental models of vascular dementia: A systematic review and meta-analysis. Annals of Neurosciences. 2024;0(0). https://doi.org/10.1177/09727531231192759

Biose IJ, Rutkai I, Clossen B, Gage G, Schechtman K, Adkisson HD 4th, Bix GJ. Recombinant Human Perlecan DV and Its LG3 Subdomain Are Neuroprotective and Acutely Functionally Restorative in Severe Experimental Ischemic Stroke. Transl Stroke Res. 2023 Dec;14(6):941-954. doi: 10.1007/s12975-022-01089-2. Epub 2022 Dec 12. PubMed PMID: 36508132; PubMed Central PMCID: PMC10258221.

Biose IJ, Bix GJ. Bilateral Carotid Artery Stenosis and Cerebral Blood Flow Outcomes. Methods Mol Biol. 2023;2616:39-46. doi: 10.1007/978-1-0716-2926-0_5. PubMed PMID: 36715926.

Biose IJ, Chastain WH, Wang H, Ouvrier B, Bix GJ. Optimizing intraluminal monofilament model of ischemic stroke in middle-aged Sprague-Dawley rats. BMC Neurosci. 2022 Dec 9;23(1):75. doi: 10.1186/s12868-022-00764-2. PubMed PMID: 36494808; PubMed Central PMCID: PMC9733327.

Trout AL, Kahle MP, Roberts JM, Marcelo A, de Hoog L, Boychuk JA, Grupke SL, Berretta A, Gowing EK, Boychuk CR, Gorman AA, Edwards DN, Rutkai I, Biose IJ, Ishibashi-Ueda H, Ihara M, Smith BN, Clarkson AN, Bix GJ. Perlecan Domain-V Enhances Neurogenic Brain Repair After Stroke in Mice. Transl Stroke Res. 2021 Feb;12(1):72-86. doi: 10.1007/s12975-020-00800-5. Epub 2020 Apr 7. PubMed PMID: 32253702; PubMed Central PMCID: PMC7803718.

Biose IJ, Dewar D, Macrae IM, McCabe C. Impact of stroke co-morbidities on cortical collateral flow following ischaemic stroke. J Cereb Blood Flow Metab. 2020 May;40(5):978-990. doi: 10.1177/0271678X19858532. Epub 2019 Jun 24. PubMed PMID: 31234703; PubMed Central PMCID: PMC7181095.

Ijomone OM, Biose IJ. Effects of Dextromethorphan on Depressive-and Cognitive-Associated Behaviors: A Sexually Dimorphic Study. Basic Clin Neurosci. 2019 Jul-Aug;10(4):393-400. doi: 10.32598/bcn.9.10.275. Epub 2019 Jul 1. PubMed PMID: 32231776; PubMed Central PMCID: PMC7101514.

Ijomone OM, Olaibi OK, Mba C, Biose IJ, Tete SA, Nwoha PU. Chronic nicotine administration does not alter cognitive or mood associated behavioural parameters. Pathophysiology. 2015 Mar;22(1):57-63. doi: 10.1016/j.pathophys.2014.12.004. Epub 2015 Jan 6. PubMed PMID: 25601213.

Ijomone OM, Olaibi OK, Biose IJ, Mba C, Umoren KE, Nwoha PU. Performance of motor associated behavioural tests following chronic nicotine administration. Ann Neurosci. 2014 Apr;21(2):42-6. doi: 10.5214/ans.0972.7531.210203. PubMed PMID: 25206059; PubMed Central PMCID: PMC4117158.

 

Lab Members

Dr. Pallavi Shrivastava

Senior Staff Scientist

pshriv@lsuhsc.edu

Skills: In vivo surgeries/ modelling, cell culture, molecular, histology and microscopy techniques.