Education

2023- AHA Fellowship
Tulane University, New Orleans, LA

2019- Ph.D. Neuroscience
University of Glasgow, Scotland, United Kingdom.

2012- M.Sc. Anatomy
University of Lagos, Lagos, Nigeria.

2010- B.Sc. Anatomy
University of Benin, Benin City, Nigeria.

Research

The central goal of my research program is to improve brain health by investigating how modifiable behaviors contribute to cognitive impairment in the context of aging and cardiovascular diseases. Leveraging both preclinical models and access to clinical biorepositories, my laboratory pursues innovative and translational approaches to slow the progression of cognitive decline while generating population-level and mechanistic insights that can inform future therapeutic strategies.

 

 

Areas of Expertise

In vitro and in vivo models of stroke

In vivo model of vascular dementia

Blood-brain barrier integrity/ permeability

Rodent behavioral/ functional assessments

Aging-related cognitive impairment

Neuroimaging

Current research Opportunities

Graduate student positions are available immediately. Contact Dr. Ifechukwude Biose (ibiose@lsuhsc.edu)

Publications

My Bibliography - NCBI (nih.gov)

https://www.ncbi.nlm.nih.gov/myncbi/ifechukwude%20joachim.biose.1/bibliography/public/

Circulating pro-angiogenic cells are preserved despite myocardial angiogenic signal deficits in HFpEF model. Shrivastava P, Raji RA, Jwayyed A, Xia H, Okon ME, Biose IJ.Sci Rep. 2026 Apr 14;16(1):17433. doi: 10.1038/s41598-026-47557-9. PMID: 41981074 

Jiakponnah NN, Biose, IJ, Fischer T et al. Alzheimer’s disease DNA methylation index (AD-DMI) and its association with late-life cognitive function. npj Dement. 2, 33 (2026). https://doi.org/10.1038/s44400-026-00085-9

Shrivastava P, Biose OD, Dahal R, Jwayyed A, Raji RA, Xia H, Lazartigues E, Biose IJ. Diurnal behavioral outcomes and BBB integrity in adult male SHR and WKY rats. Sci Rep. 2025 Nov 24;15(1):41637. doi: 10.1038/s41598-025-25585-1. PubMed PMID: 41285975; PubMed Central PMCID: PMC12644676.

Biose IJ, Chastain W, Solch-Ottaiano RJ, Grayson V, Wang H, Banerjee S and Bix GJ. Effect of exercise on experimental models of vascular dementia: A systematic review and meta-analysis. Annals of Neurosciences. 2024;0(0). https://doi.org/10.1177/09727531231192759

Biose IJ, Rutkai I, Clossen B, Gage G, Schechtman K, Adkisson HD 4th, Bix GJ. Recombinant Human Perlecan DV and Its LG3 Subdomain Are Neuroprotective and Acutely Functionally Restorative in Severe Experimental Ischemic Stroke. Transl Stroke Res. 2023 Dec;14(6):941-954. doi: 10.1007/s12975-022-01089-2. Epub 2022 Dec 12. PubMed PMID: 36508132; PubMed Central PMCID: PMC10258221.

Biose IJ, Bix GJ. Bilateral Carotid Artery Stenosis and Cerebral Blood Flow Outcomes. Methods Mol Biol. 2023;2616:39-46. doi: 10.1007/978-1-0716-2926-0_5. PubMed PMID: 36715926.

Biose IJ, Chastain WH, Wang H, Ouvrier B, Bix GJ. Optimizing intraluminal monofilament model of ischemic stroke in middle-aged Sprague-Dawley rats. BMC Neurosci. 2022 Dec 9;23(1):75. doi: 10.1186/s12868-022-00764-2. PubMed PMID: 36494808; PubMed Central PMCID: PMC9733327.

Trout AL, Kahle MP, Roberts JM, Marcelo A, de Hoog L, Boychuk JA, Grupke SL, Berretta A, Gowing EK, Boychuk CR, Gorman AA, Edwards DN, Rutkai I, Biose IJ, Ishibashi-Ueda H, Ihara M, Smith BN, Clarkson AN, Bix GJ. Perlecan Domain-V Enhances Neurogenic Brain Repair After Stroke in Mice. Transl Stroke Res. 2021 Feb;12(1):72-86. doi: 10.1007/s12975-020-00800-5. Epub 2020 Apr 7. PubMed PMID: 32253702; PubMed Central PMCID: PMC7803718.

Biose IJ, Dewar D, Macrae IM, McCabe C. Impact of stroke co-morbidities on cortical collateral flow following ischaemic stroke. J Cereb Blood Flow Metab. 2020 May;40(5):978-990. doi: 10.1177/0271678X19858532. Epub 2019 Jun 24. PubMed PMID: 31234703; PubMed Central PMCID: PMC7181095.

Ijomone OM, Biose IJ. Effects of Dextromethorphan on Depressive-and Cognitive-Associated Behaviors: A Sexually Dimorphic Study. Basic Clin Neurosci. 2019 Jul-Aug;10(4):393-400. doi: 10.32598/bcn.9.10.275. Epub 2019 Jul 1. PubMed PMID: 32231776; PubMed Central PMCID: PMC7101514.

Ijomone OM, Olaibi OK, Mba C, Biose IJ, Tete SA, Nwoha PU. Chronic nicotine administration does not alter cognitive or mood associated behavioural parameters. Pathophysiology. 2015 Mar;22(1):57-63. doi: 10.1016/j.pathophys.2014.12.004. Epub 2015 Jan 6. PubMed PMID: 25601213.

Ijomone OM, Olaibi OK, Biose IJ, Mba C, Umoren KE, Nwoha PU. Performance of motor associated behavioural tests following chronic nicotine administration. Ann Neurosci. 2014 Apr;21(2):42-6. doi: 10.5214/ans.0972.7531.210203. PubMed PMID: 25206059; PubMed Central PMCID: PMC4117158.

 

Lab Members