School of Medicine

Department of Obstetrics & Gynecology

Below are clinical trials open pertaining to gynecologic cancers with LSU Health New Orleans.

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Cervical Cancer  

SWOG s2012 

Evaluating the addition of the immunotherapy drug atezolizumab to standard chemotherapy treatment for advanced or metastatic neuroendocrine carcinomas that originate outside the lung.

C-145-04

A Phase II, Multicenter Study to Evaluate Efficay and Safety Using Autologous Tumor Infiltrating Lymphocytes (LN-145) in Patients with Recurrent, Metastatic or Persistent Cervical Carcinoma.    

GOG-3043 

A Randomized Controlled Trial of Robotic vs. Open Radical Hysterectomy for Cervical Cancer (ROCC Trial)

OU-SCC-STAR

Phase II trial of niraparib in combination with dostarlimab in patients with recurrent or progressive cervix cancer (STAR)

 

Ovarian Cancer      

NRG GY-019

Randomized Phase III Trial of Paclitaxel/Carboplatin Followed by Maintenance Letrozole versus Letrozole monotherapy in Stage II-IV Low Grade Serous Carcinoma

GlORIOSA/ GOG-3078

Randomized, multicenter, open-label, phase 3 study of mirvetuximab soravtansine in combination with bevacizumab versus bevacizumab alone as maintenance therapy for patients with FRα-positive recurrent platinum-sensitive epithelial ovarian, fallopian tube

ACRIVON ACR-368-201/GOG 3082

A phase Ib/2 basket study of CR-368 as monotherapy and in combination with gemcitabine in adult subjects with platinum-resistant ovarian carcinoma, endometrial adenocarcinoma and urothelial carcinoma based on ACRIVON Oncosignature Status.

 

Uterine Cancer

GOG 3083/XPORT EC-042 

Selinexor in Maintenance Therapy After Systemic Therapy for Participants with p53 Wild-Type, Advanced or Recurrent Endometrial Carcinoma (XPORT-EC-042) Rare Tumors.

A092104 

Testing Olaparib and Temozolomide versus the Usual Treatment for Uterine Leiomyosarcoma After Chemotherapy has Stopped Working.

SISTER STUDY

A randomized controlled trial looking at different modalities of social support for black women with endometrial cancer. 

Endometrial Cancer Molecularly Targeted Therapy Consortium

NRG GY026

A Phase II/III Study of Paclitaxel/Carboplatin Alone or Combined with Either Trastuzumab and Hyaluronidase-oysk (HERCEPTIN HYLECTA) or Pertuzumab, Trastuzumab, and Hyaluronidase-zzxf (PHESGO) in HER2 Positive, Stage I-IV Endometrial Serous Carcinoma or Carcinosarcoma

NRG CC010

A Phase III Trial Of The Impact Of Sentinel Lymph Node Mapping On Patient Reported Lower Extremity Limb Dysfunction In Endometrial Cancer

FIERCE -OUSCC MISP 58084

A phase Ib trial of vaginal cuff brachytherapy + pembrolizumab (MK3475) followed by 3 cycles of dose dense paclitaxel/q21 day carboplatin + pembrolizumab (MK3475) in high intermediate risk endometrial cancer

ACRIVON ACR-368-201/GOG 3082

A phase Ib/2 basket study of CR-368 as monotherapy and in combination with gemcitabine in adult subjects with platinum-resistant ovarian carcinoma, endometrial adenocarcinoma and urothelial carcinoma based on ACRIVON Oncosignature Status.

Cancer Control

DCP-001

Use of a Clinical Trial Screening Tool to Address Cancer Health Disparities in teh NCI Community Oncology Research Program (NCORP)

 

Cancer Symptom Management

URC 21038/ DiRECT

DiRECT: An Observational Research Study for Cancer Patients on Immune Checkpoint Inhibitors

NRG CC008

A Non-Randomized Prospective Clinical Trial Comparing the Non-Inferiority of Salpingectomy to Salpingo-oophorectomy to Reduce the Risk of Ovarian Cancer Among BRCA1 Carriers [SOROCk]

URCC 19185

Multicenter Randomized Controlled Trial Comparing Brief Behavioral Therapy for Cancer related Insomnia and Healthy Eating Education Learning