Jorgelina Calandria, PhD
Assistant Professor, Research
in Neurology and Neuroscience
Neuroscience Center of Excellence
School of Medicine, LSU Health
2020 Gravier Street, 8th floor, 828
New Orleans, LA 70112
Office Phone: (504) 599-0874
Lab Phone: (504) 599-0908
FAX: (504) 568-5801
email: JCalan@lsuhsc.edu
Degrees
2009: Ph.D. in Neurosciences, Louisiana State University Health, New Orleans, School of Graduate Studies.
2002: Licenciada en Ciencias Biologicas, area Neurobiologia Molecular
Equivalent: Bachelor in Biological Sciences and Master degree in Molecular Biology and Neuroscience.
Facultad de Ciencias Exactas y Naturales, UBA, Buenos Aires Argentina.
1992: Analytical Chemistry Technical degree: National Technical School ENET Nº 27 Hipolito Yrigoyen, Buenos Aires. Argentina.
Research Interests
My interests are centered in the mechanisms of neuroprotection exerted by bioactive lipids derived from docosahexaenoic acid (DHA). We focus on age-related neurodegenerative and other pathologies related with dopamine neuronal systems, for instance, Parkinson’s disease and Lewy body dementia, seeking to counteract the effects of dysregulated phospholipase A2 group VI. For this purpose, we utilize an acute and a chronic rat model of Parkinsonian disorders with bioactive lipids. Of special interest are the effects of lipid mediators targeting microglia and astrocytes and their transformation into pro-survival phenotypes.
Bio
Positions
December 2016 - Present. Assistant Professor-Research. Neuroscience Center & Department of Cell Biology and Anatomy, Louisiana State University Health.
January 2010- November 2016. Post-Doctoral Researcher. Neuroscience Center of Excellence, Louisiana State University Health.
March-December 2003. Research Associate. Neuroscience Center of Excellence, Louisiana State University Health.
August 1997- February 2003. Undergrad Student Researcher. Fundación Instituto Leloir (Former Fundación Campomar), Buenos Aires, Argentina.
May 1999-June 2000. Undergrad Student Researcher. Instituto de Investigaciones Biotecnológicas, IIB-INTECH Universidad Nacional de San Martin (UNSAM), Buenos Aires Argentina.
1999-2000. Undergrad Teaching Assistant. Facultad de Ciencias Exactas y Naturales, UBA. Buenos Aires, Argentina.
Teaching Activities
- Team Up (Interprofessional Education): Grader
- Molecular Neurobiology (Graduate Studies-Neuro250)
- Molecular Biology (Graduate Studies-Inter122)
Mentoring
LSU-Health, School of Graduate Studies Faculty
- Co-Mentoring
- Candidate for PhD: Gethein Andrew
- Candidate for MD/PhD: Jeff Ji
- Endure Scholars (The NIH Blueprint initiative "Enhancing Neuroscience Diversity through Undergraduate Research Education Experiences)
- Tendayi Mpofu (second year0
- Tonya Chaney (first year)
- REU Summer program Students: Research Experiences for Undergraduates-National Science Foundation (NSF)
- 2019 Jonathan Abshier
- 2021-2022 Alexandra Minnard
- 2023 Jeanne Dugas
Committees & Administrative Responsibilities
- Course Evaluation Committee (CEC)
- Faculty Assembly
Honors
1999 - 2000. Research Student Fellowship Award, Instituto de Investigaciones Biotecnológicas, Universidad Nacional de San Martin (UNSAM).
2001 - 2003. Research Student Fellowship Award. Fundación Avanzar.
Selected Publications
- Calandria JM, Bhattacharjee S, Maness NJ, Kautzmann MI, Asatryan A, Gordon WC, Do KV, Jun B, Mukherjee PK, Petasis NA, Bazan NG. 2022. Elovanoids downregulate SARS-CoV-2 cell-entry, canonical mediators and enhance protective signaling in human alveolar cells. Sci Rep. 11(1):12324. PMID: 34112906
- Rugolo F, Bazan NG, Calandria J, Jun B, Raschellà G, Melino G, Agostini M. 2021. The expression ELOVL4, repressed by MYCN, defines neuroblastoma patients with good outcome. Oncogene. 40(38):5741-5751. PMID: 34333551
- Calandria JM, Sharp MW, Bazan NG. 2015. The Docosanoid Neuroprotectin D1 Induces TH-Positive Neuronal Survival in a Cellular Model of Parkinson's Disease. Cell Mol Neurobiol. 35(8):1127-36. PMID: 26047923.
- Belayev L, Mukherjee PK, Balaszczuk V, Calandria JM, Obenaus A, Khoutorova L, Hong SH, Bazan NG. Neuroprotectin D1 upregulates Iduna expression and provides protection in cellular uncompensated oxidative stress and in experimental ischemic stroke. Cell Death Differ. 2017 Jun;24(6):1091-1099.
- Rice DS, Calandria JM, Gordon WC, Jun B, Zhou Y, Gelfman CM, Li S, Jin M, Knott EJ, Chang B, Abuin A, Issa T, Potter D, Platt KA, Bazan NG. Adiponectin receptor 1 conserves docosahexaenoic acid and promotes photoreceptor cell survival. Nat Commun. 2015 Mar 4;6:6228. doi: 10.1038/ncomms7228. Erratum in: Nat Commun. 2015;6:7225.
- Calandria JM, Asatryan A, Balaszczuk V, Knott EJ, Jun BK, Mukherjee PK, Belayev L, Bazan NG. 2015. NPD1-mediated stereoselective regulation of BIRC3 expression through cREL is decisive
for neural cell survival. Cell Death Differ. 22(8):1363-77. PMID: 25633199
- Calandria JM, Mukherjee PK, de Rivero Vaccari JC, Zhu M, Petasis NA, Bazan NG. Ataxin-1 poly(Q)-induced proteotoxic stress and apoptosis are attenuated in neural
cells by docosahexaenoic acid-derived neuroprotectin D1. J Biol Chem. 2012 Jul 6;287(28):23726-39. PMID: 22511762
- Calandria JM, Marcheselli VL, Mukherjee PK, Uddin J, Winkler JW, Petasis NA, Bazan NG. 2009 Selective Survival Rescue in 15-Lipoxygenase-1-deficient Retinal Pigment Epithelial
Cells by the Novel Docosahexaenoic Acid-derived Mediator, Neuroprotectin D1. J Biol Chem. 284:17877-82. PMCID: PMC2719426
- Tafet GE, Idoyaga-Vargas VP, Abulafia DP, Calandria JM, Roffman SS, Chiovetta A, Shinitzky M. Correlation between cortisol level and serotonin uptake in patients with chronic stress
and depression. Cogn Affect Behav Neurosci. 1:388-393, 2001. PMID: 12467090
- Alperin MD, Calandria JM, Carminatti H, Idoyaga-Vargas VP. Altered protein mannosylation in developing cerebral cortex by streptomycin. Neuroreport11:3569-3572, 2000. PMID: 11095520
Complete List of Published Work in My Bibliography: https://www.ncbi.nlm.nih.gov/myncbi/jorgelina.calandria.1/bibliography/public/