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Diptasri M. Mandal, M.Sc., M.S., Ph.D.
Diptasri M. Mandal, M.Sc., M.S., Ph.D.
Professor, Department of Genetics
Interim Associate Dean, School of Graduate Studies
Professor, Department of Genetics
Interim Associate Dean, School of Graduate Studies
533 Bolivar Street, Room 647
New Orleans, LA 70112
Phone: (504) 568- 6156
dmanda@lsuhsc.edu
Degrees
B.Sc. Zoology - 1984
Calcutta University, Calcutta, India
M.Sc. Zoology with specialization in Entomology - 1986
Burdwan University, Burdwan, India
M.S. Biology - 1991
University of Louisiana, Monroe, LA
Ph.D. Human Genetics, Biometry minor - 1996
Louisiana State University Health Sciences Center (Advisor: Dr. Joan Bailey-Wilson)
Bio
Dr. Diptasri M. Mandal is a Professor in the Department of Genetics at Louisiana State University Health Sciences Center. She received her PhD. in Human Genetics from the Department of Biometry and Genetics at LSU Health Sciences Center in 1996. She joined the Department of Medicine in 1997, and in June 2000 moved to the Department of Genetics. She ascended through the academic ranks and was promoted to Professor in 2015.
The major focus of her research is genetic studies of complex human traits and diseases, especially cancer. Studies are underway to identify disease susceptible loci for hereditary prostate cancer and lung cancer using linkage, association, and next generation sequencing analyes. She is an invited member of International Consortium of Prostate Cancer Genetics (ICPCG), UK PRACTICAL Consortium, and Genetic Epidemiology of Lung Cancer Consortium (GELCC).
Research Interests
- Genetic studies of familial lung cancer and health diparity
- Genetic studies of familial prostate cancer and health disparity
Teaching Activities
Course Director: Genetic Epidemiology and Population Genetics (GENET 236)
Lecturer: Medical Genetics (GENET 100), Genetics (INTER 141), Cancer Molecular Genetics and Applications (GENET 245), Clinical Genetics (PYAS 6574), and Cancer Epidemiology (EPID 6222)
Committees & Administrative Responsibilities
Departmental Committees
2002-2021. Chair, Graduate Student Admission Committee
2009-2023. Chair, Promotion & Tenure Committee
2009-present. Chair. Graduate Student Oversight Committee
2010-present. Chair. Curriculum Committee
School of Medicine Committees
2001-present. Member, Graduate Advisory Council
2003-2019, Member, Council of Professional Conduct
2006-2024. Chair, Curriculum Committee, Graduate School
2023-present. Member, Graduate School Mentoring Committee
2014-present. Member, Research Committee, Graduate School
Administrative Responsibilities
2000-present. Graduate Student Coordinator, Department of Genetics
2024-present. Interim Associate Dean, School of Graduate Studies
Selected Publications
D.M. Mandal, A.F.Wilson, R.C. Elston, K. Weissbecker, B. J. Keats, J. E. Bailey-Wilson. Effect of misspecification of allele frequencies on the Type I error of model-free linkage analysis. Human Heredity. 2000. 50:126-132.
D. M. Mandal, A. F. Wilson and J. E. Bailey-Wilson. Effects of Misspecification of Allele Frequencies on the Power of Haseman-Elston Sib-pair Linkage Method for Quantitative Traits. American Journal of Medical Genetics. 2001.103:308-313.
J. E. Bailey-Wilson, C. I. Amos, S. Pinney, G. M. Petersen, M. de Andrade, J. S. Wiest, P. Fain, A. G. Schwartz, M. You, W. Franklin, C. Klein, A. Gazdar, H. Rothschild, D. M. Mandal, T. Coons, J. Slusser, J. Lee, C. Gaba, E. Kupert, A. Perez, X. Zhou, D. Zeng, Q. Liu, D. Seminara, J. Minna, M. Anderson. A major lung cancer susceptibility locus maps to chromosome 6q23-25. American Journal of Human Genetics. 2004. 75:460-484.
M. Wang, H. Vikis, Y. Wang, D. Jia, D. Wang, L. J. Bierut, J. E. Bailey-Wilson, C. I. Amos, S. M. Pinney, G. P. Peterson, M. de Andrade, P. Yang, J. S. Wiest, P. R. Fain, A. G. Schwartz, A. Gazdar, J. Minna, C. Gaba, H. Rothschild, D. M. Mandal, E. Kupert, D. Seminara, Y. Liu, J. Clark, M. Watson, A. Viswanathan, R. Govindan, M. W. Anderson, M. You. Identification of a novel tumor suppressor gene p34 on human chromosome 6q25.1. Cancer Research. 2007. 67:93-99.
D. M. Mandal, O. Sartor, S.L. Halton, D.E. Mercante, J.E. Bailey-Wilson, W. Rayford. Identification of Prostate Cancer Cases in Louisiana and a Comparison of Prostate Cancer Specific Clinical Data on African-American and Caucasian Males with and without Family History. Prostate Cancer and Prostatic Diseases. 2008. 11:274-279.
P. Liu, H.G. Vikis, D. Wang, Y. Lu, Y. Wang, A.G. Schwartz, S.M. Pinney, P. Yang, M. de Andrade, G.M. Petersen, J.S. Wiest, P.R. Fain, A. Gazdar, C. Gaba, H. Rothschild, D.M. Mandal, T. Coons, J. Lee, E. Kupert, D. Seminara, J. Minna, J.E. Bailey-Wilson, M.R. Spitz, T. Eisen, R.S. Houlston, C.I. Amos, M.W. Anderson, M. You. Familial aggregation of common sequence variants on 15q24-25.1 in lung cancer. J Natl Cancer Inst. 2008. 100:1326-30.
M. You, D. Wang, P. Liu, H. Vikis, M. James, Y. Lu, Y. Wang, M. Wang, D. Jia, Y. Liu, L.J. Bierut, P. Yang, Z. Sun, Y. Wu, W. Zheng, X. Shu, J. Long, Y. Gao, Y. Xiang, W. Chow, N. Rothman, S.M. Pinney, G.M. Petersen, M. de Andrade, J.S. Wiest, P.R. Fain, A.G. Schwartz, A. Gazdar, C. Gaba, H. Rothschild, D. M. Mandal , J. Lee, E. Kupert, D. Seminara, J. Minna, J.E. Bailey-Wilson, C. I. Amos, and M.W. Anderson. RGS17 is a candidate for the lung cancer susceptibility locus on chromosome 6q23-25. Clinical Cancer Research.2009. 15:2666-74.
C.I. Amos, S.M. Pinney, Y. Li, E. Kupert, J. Lee, M.A. de Andrade, P. Yang, A.G. Schwartz, P.R. Fain, A. Gazdar, J. Minna, J.S. Wiest, D. Zeng, H. Rothschild, D. M. Mandal, M. You, T. Coons, C. Gaba, J.E. Bailey-Wilson, M.W. Anderson. A susceptibility locus on chromosome 6q greatly increases lung cancer risk among light and never smokers. Cancer Research. 2010. 70:2359-67.
E.M. Ledet, O. Sartor, W. Rayford, J.E. Bailey-Wilson, D.M. Mandal. Suggestive evidence of linkage identified at chromosomes 12q24 and 2p16 in African American prostate cancer families from Louisiana. Prostate. 2012. 72:938-47.
E.M. Ledet, X. Hu, O. Sartor, W. Rayford, M. Li, D. M. Mandal. Characterization of germline copy number variation in high-risk African American families with prostate cancer. Prostate. 2013. 73:614-23.
A.M. Musolf, B.A. Moiz, H. Sun, C.W. Pikielny, Y. Bossé, D.M. Mandal, M. de Andrade, C. Gaba, P. Yang, Y. Li, M. You, R. Govindan, R.K. Wilson, E.Y. Kupert, M.W. Anderson, A.G. Schwartz, S.M. Pinney SM, C.I. Amos, J.E. Bailey-Wilson. Whole Exome Sequencing of Highly Aggregated Lung Cancer Families Reveals Linked Loci for Increased Cancer Risk on Chromosomes 12q, 7p and 4q. Cancer Epidemiol Biomarkers Prev. 2020;29(2):434‐442. doi:10.1158/1055-9965.EPI-19-0887. PubMed PMID: 31826912. PubMed PMID: 31826912.
Musolf, A. M., Simpson, C. L., Moiz, B. A., Pikielny, C. W., Middlebrooks, C. D., Mandal, D., de Andrade, M., Cole, M. D., Gaba, C., Yang, P., You, M., Li, Y., Kupert, E. Y., Anderson, M. W., Schwartz, A. G., Pinney, S. M., Amos, C. I., & Bailey-Wilson, J. E. (2021). Genetic Variation and Recurrent Haplotypes on Chromosome 6q23-25 Risk Locus in Familial Lung Cancer. Cancer research vol. 81,12 (2021): 3162-3173. doi:10.1158/0008-5472.CAN-20-3196
Zhang G, Wang Z, Bavarva J, Kuhns KJ, Guo J, Ledet EM, Qian C, Lin Y, Fang Z, Zabaleta J, Valle LD, Hu JJ, Mandal D, Liu W. A Recurrent ADPRHL1 Germline Mutation Activates PARP1 and Confers Prostate Cancer Risk in African American Families. Mol Cancer Res. 2022 Dec 2;20(12):1776-1784. doi: 10.1158/1541-7786.MCR-21-0874. PubMed PMID: 35816343.
Li Y, Xiao X, Li J, Han Y, Cheng C, Fernandes GF, Slewitzke SE, Rosenberg SM, Zhu M, Byun J, Bossé Y, McKay JD, Albanes D, Lam S, Tardon A, Chen C, Bojesen SE, Landi MT, Johansson M, Risch A, Bickeböller H, Wichmann HE, Christiani DC, Rennert G, Arnold SM, Goodman GE, Field JK, Davies MPA, Shete S, Le Marchand L, Liu G, Hung RJ, Andrew AS, Kiemeney LA, Sun R, Zienolddiny S, Grankvist K, Johansson M, Caporaso NE, Cox A, Hong YC, Lazarus P, Schabath MB, Aldrich MC, Schwartz AG, Gorlov I, Purrington KS, Yang P, Liu Y, Bailey-Wilson JE, Pinney SM, Mandal D, Willey JC, Gaba C, Brennan P, Xia J, Shen H, Amos CI. Lung cancer in ever- and never-smokers: findings from multi-population GWAS studies. Cancer Epidemiol Biomarkers Prev. 2024 Jan 5. doi: 10.1158/1055-9965.EPI-23-0613. Epub ahead of print. PMID: 38180474.
Additional Info
Additional publications:
https://www.ncbi.nlm.nih.gov/myncbi/1LMflDk3CebAc/bibliography/public/