Quicklinks▼
Careers
Citrix Storefront
Contact
Departments & Centers
Donate
Emergency Preparedness
Find Employees
LSU Health New Orleans
Intranet
Moodle
myLSUHSC
Office 365
Office 365 Mail
Patient Care
Remote VPN
Self Service
LSU Health New Orleans
Michael S. Lan, PhD
Professor, Department of Genetics
Louisiana State University Health Sciences Center, New Orleans
Children’s Hospital Professorship of Pediatric Research
Professor, Department of Genetics
Louisiana State University Health Sciences Center, New Orleans
Children’s Hospital Professorship of Pediatric Research
Degrees
1976 - B.S. in Chemistry, SooChow University, Taiwan, R.O.C.
1980 - M.S. in Molecular Biology, National Tsing Hua University, Taiwan, R.O.C.
1986 - Ph.D. in Microbiology and Immunology, Duke University, Durham, NC USA
Research Interests
- Study of transcription factor in neuroendocrine (NE) differentiation and transformation.
- Signaling pathways involved in NE development.
- Molecular targeting transcription factor and signaling pathway against NE tumors.
- Evaluation of NE biomarker diagnosis and drug therapeutic discovery.
- Study of insulin autoimmunity, tolerance, and type 1 diabetes (T1D).
Selected Publications
- Chen, C., Breslin, M.B., and Lan, M.S.: Sonic hedgehog signaling pathway regulates INSM1 transcription factor in neuroendocrine lung cancer. Cell. Signal. 46: 83-91, 2018.
- Wang, L., Sun, Z.S., Xiang, B., Wei, C., Wang, Y., Sun, K., Chen, G., Lan, M.S., Carmona, G.N., Notkins, A.L., and Cai, T.: Targeted deletion of Insm2 in mice result in reduced insulin secretion and glucose intolerance. J. Transl. Med., 16: 297-305, 2018.
- Chen, C., Breslin, M.B., Guidry, J.J., and Lan, M.S.: 5’-iodotubercidin represses insulinoma-associated-1 expression, decreases cAMP levels, and suppresses human neuroblastoma cell growth. J. Biol. Chem.,294: 5456-5465, 2019.
- Chen, C., Notkins, A.L., and Lan M.S.: Insulinoma-associated-1 (IA-1/INSM1): From neuroendocrine tumor marker to cancer therapeutics. In press. Mol. Cancer Res., 17(8): 1597-1604, 2019.
- Chen C, Lan M.S.: A promoter-driven assay for INSM1-associated signaling pathway in NB. Cell Signal., 76: 109785, 2020
- Chen, C. and Lan, M.S.: Interplay: the essential role between INSM1 and N-Myc in aggressive NB. Biology, 11: 1376, 2022.
- Chen, C., Wu, J., Hicks, C., and Lan, M.S.: Repurposing a plant alkaloid homoharringtonine targets INSM1 in N-Myc-activated NB, Cell. Signal., 109: 110753, 2023.
- Lan, M.S. and Chen, C.: Small molecules targeting INSM1 for the treatment of high-risk neuroblastoma. Biology, 12: 1134, 2023.