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LSU Health New Orleans
Paloczi, Janos I., PhD
Paloczi, Janos I., PhD
Assistant Professor
Department of Physiology
Assistant Professor
Department of Physiology
533 Bolivar Street, Room 309
New Orleans, LA 70112
(504)568-6197
jpaloc@lsuhsc.edu
Degrees
BSc in teaching Biology and Environmental protection, College of Nyiregyhaza, Hungary
MSc in teaching Biology, University of Debrecen, Hungary
MSc in Molecular Biology and Medical Biology, University of Debrecen, Hungary
PhD in in Biochemistry, Biophysics, Molecular and Cell Biology, University of Szeged, Hungary
Postdoctoral and Research Fellowships at the National Institutes of Health, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland
Research Interests
Our research aims to investigate the intricate crosstalk between the gut and heart in alcohol misuse-related pathologies. By employing a multidisciplinary approach, including echocardiography, cardiac pressure-volume catheterization, laser speckle contrast imaging, cell culture models, RNAscope, histology, or other in vitro techniques, we strive to unravel the complex interplay among gut bacteria-derived substances, cardiovascular endocannabinoids, and dysfunction associated with alcohol misuse. Understanding this relationship is crucial, as endocannabinoid signaling has significant impacts on cardiac performance, vascular tone, and inflammation. Our findings will contribute to a deeper understanding of the pathophysiology involved, potentially identifying novel therapeutic targets for mitigating cardiovascular dysfunction associated with the gut-heart axis in individuals with alcohol use disorder.
Teaching Activities
- Journal club co-organizer for undergraduate and post-baccalaureate interns (title: “Cannabis: Curse or Cure” focusing on the basics of (endo)cannabinoid signaling, crystal structure of cannabinoid receptors and their pharmacology, the effects of plant-derived cannabinoids).
- Mentoring NIH post-baccalaureates and summer interns.
Selected Publications
- Li X.,Chang H, Bouma J, de Paus LV, Mukhopadhyay M, Paloczi J, Mustafa M, van der Horst C, Kumar SS, Wu L, Yu Y, van der Berg R, Janssen APA, Lichtman A, Liu ZJ, Pacher P, van der Stelt M, Heitman LH. Structural basis of selective cannabinoid CB2 receptor activation. Nat Commun. 2023.
- Guillot A, Guerri L, Feng D, Kim SJ, Ahmed YA, Paloczi J, He Y, Schuebel K, Dai S, Liu F, Pacher P, Kisseleva T, Qin X, Goldman D, Tacke F, Gao B. Bile acid-activated macrophages promote biliary epithelial cell proliferation through integrin αvβ6 upregulation following liver injury. J Clin Invest. 2021.
- Mock ED, Mustafa M, Gunduz-Cinar O, Cinar R, Petrie GN, Kantae V, Di X, Ogasawara D, Varga ZV, Paloczi J, Miliano C, Donvito G, van Esbroeck ACM, van der Gracht AMF, Kotsogianni I, Park JK, Martella A, van der Wel T, Soethoudt M, Jiang M, Wendel TJ, Janssen APA, Bakker AT, Donovan CM, Castillo LI, Florea BI, Wat J, van den Hurk H, Wittwer M, Grether U, Holmes A, van Boeckel CAA, Hankemeier T, Cravatt BF, Buczynski MW, Hill MN, Pacher P, Lichtman AH, van der Stelt M. Discovery of a NAPE-PLD Inhibitor That Modulates Emotional Behavior in Mice. Nat Chem Biol. 2020.
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Paloczi J, Matyas C, Cinar R, Varga VZ, Hasko G, Schindler TH, Kunos G, and Pacher P, Alcohol binge-induced cardiovascular dysfunction involves endocannabinoid-CB1-R signaling. J Am Coll Cardiol Basic Trans Science. 2019.
- Editorial Commentary: Montecucco F, Carbone F. The Detrimental Effects of Alcohol and Cannabinoids on Cardiovascular Function. J Am Coll Cardiol Basic Trans Science. 2019.
Varga ZV, Matyas C, Erdelyi K, Cinar R, Nieri D, Chicca A, Nemeth BT, Paloczi J, Lajtos T, Corey L, Hasko G, Gao B, Kunos G, Gertsch J, Pacher P. Beta-caryophyllene protects against alcoholic steatohepatitis by attenuating inflammation and metabolic dysregulation in mice. Br J Pharmacol. 2017.
- Mukhopadhyay P, Horváth B, Rajesh M, Varga ZV, Gariani K, Ryu D, Cao Z, Holovac E, Park O, Zhou Z, Xu MJ, Wang W, Godlewski G, Paloczi J, Nemeth BT, Persidsky Y, Liaudet L, Haskó G, Bai P, Hamid Boulares A, Auwerx J, Gao B, Pacher P. PARP inhibition protects against alcoholic and nonalcoholic steatohepatitis. J Hepatol. 2017.
- Pálóczi J, Varga ZV, Apáti Á, Szebényi K, Sarkadi B, Madonna R, De Caterina R, Csont T, Eschenhagen T, Ferdinandy P, Görbe A. Exogenous Nitric Oxide Protects Human Embryonic Stem Cell-Derived Cardiomyocytes against Ischemia/Reperfusion Injury. Oxid Med Cell Longev. 2016.
- Kiss K, Csonka C, Pálóczi J, Pipis J, Görbe A, Kocsis GF, Murlasits Z, Sárközy M, Szűcs G, Holmes CP, Pan Y, Bhandari A, Csont T, Shamloo M, Woodburn KW, Ferdinandy P, Bencsik P. Novel, selective EPO receptor ligands lacking erythropoietic activity reduce infarct size in acute myocardial infarction in rats. Pharmacol Res. 2016.
- Bencsik P*, Pálóczi J*, Kocsis GF, Pipis J, Belecz I, Varga ZV, Csonka C, Görbe A, Csont T, Ferdinandy P. Moderate inhibition of myocardial matrix metalloproteinase-2 by ilomastat is cardioprotective. Pharmacol Res. 2014. *These authors contributed equally to this work.