School of Medicine

Department of Orthopaedics

Andrew Chapple, PhD

FACULTY

Andrew Chapple

Assistant Professor
Director - Biostatistics

Interdisciplinary Oncology

Academic Office

Stanley S. Scott Cancer Center
533 Bolivar St
LSU Health Sciences Center
New Orleans, LA 70112

Bio

Dr. Chapple’s primary role as Director of Biostatistics is planning cancer clinical trials in mice, humans, and cell lines – while also executing statistical analyses. Dr. Chapple is an expert in adaptive clinical trial designs, particularly Bayesian methods. His 2019 paper “A hybrid Phase I-II/III clinical trial design allowing for dose re-optimization in Phase III” proposed a new framework for seamless drug development through the three stages of clinical trial design. This paper was recognized globally by the statistical community when it received the award for “Best Paper” from Biometrics, a top tier statistical journal. Dr. Chapple has received worldwide recognition for his contributions to adaptive clinical trial design methodology and he hopes this expertise can propel his institution towards innovative cancer therapies, rapid advances in treatment of chronic diseases, and the long-term goal of personalized/precision medicine.

Dr. Chapple has produced many new trial designs and methods, which are accompanied with user-friendly R packages. Dr. Chapple trained under Dr. Peter Thall at MD Anderson, who is a pioneer in Bayesian adaptive trials. He later refined these skills working with cancer researchers from other institutions. Dr. Chapple’s adaptive trial designs were used to dose-find in pediatric brain tumors in a trial conducted at Harvard and the Dana Farber Cancer Center.

Dr. Chapple has designed hundreds of studies and has supported many research departments at LSUHSC including: Orthopedics, OBGYN, Hematology Oncology, Dermatology, Oral Surgery, Endodontics, Cancer, Virology, Cellular Biology, Inflammation, and treatment disparities research. As a joint professor in Orthopedics, Dr. Chapple works on large scale electronic records databases which requires processing longitudinal information from patients on hospital encounters, diagnoses, procedures, prescriptions, and lab values.

Education

Ph.D., Rice University, May 2018
M.S., Rice University, May 2018 Major: Statistics

M.Ap.St, Louisiana State University, May 2014
Major: Applied Statistics

B.S. Louisiana State University, May 2012
Major: Mathematics

Publications

1. Han, K.J., Pitman, W.D., Chapple, A. (2014). Moisture Concentration Variation of Silages Produced on Commercial Farms in the South-Central USA. Asian-Australasian Journal of Animal Sciences. 2014;27(10):1436-1442.

2. Chapple, A. (2016) A Bayesian Reversible Jump Piecewise Hazard approach for modeling rate changes in mass shootings. Journal of Economics and Econometrics. 59 (3). 19-31.

3. Liru, H., Chapple, A.G., Liao, Z., Komaki, R., Thall, P.F., Lin SH. (2016) Bayesian regression analyses of radiation modality effects on pericardial and pleural effusion and survival in esophageal cancer. Journal of Radiation Oncology. 121 (1): 70-74.

4. Chapple, A.G., Vannucci, M., Thall, P.F., Lin, S.H. (2017). Bayesian variable selection for a semi-competing risks model with three hazard functions. Journal of Computational Statistics and Data Analysis. 112: 170-185.

5. Chapple, A.G. (2018). Modeling ISIL terror attacks and their fatality rates with a Bayesian reversible jump marked point process. Journal of Economics and Econometrics. Economics and Econometrics Society. 61(3): 1-14.

6. Chapple, A.G., Thall, P.F. (2018). Subgroup-specific dose finding in phase I clinical trials based on time to toxicity allowing adaptive subgroup combination. Journal of Pharmaceutical Statistics. 1-16.

7. Peak T.C., Chapple, A.G., Coon, G., Hemal, A. (2018). Utilizing a Semi-Competing Risk Model to Predict Perioperative and Oncologic Outcomes after Radical Cystectomy. British Urology Journal. 10 (11): 317-326

8. Chapple, A.G., Thall, P.F. (2018). A hybrid phase I‐II/III clinical trial design allowing dose re‐optimization in phase III. Biometrics. 1– 11. https://doi.org/10.1111/biom.12994

9. Peak, T., Russell, G.B., Dutta, R., Rothberg, M., Chapple, A.G., Hemal, A.K. (2018). An NCDB-based Nomogram to Predict Lymph Node Metastasis in Penile Cancer. BJU International. 123. 10.1111/bju.14652.

10. Christensen, B.J., Chapple, A.G., King, B.J. (2018). How much weight loss can be expected after treating mandibular fractures? Journal of Oral and Maxillofacial Surgery.

11. Chapple, A. G., Wojcik, J. J., & McDaniel, L. S. (2019). A regression based phase I clinical trial for late-onset toxicities without clinician elicitation. Contemporary clinical trials communications, 14, 100327. doi:10.1016/j.conctc.2019.100327

12. Peak, T., Su, Y., Chapple, A.G., Chryr,, J., Pollack, J., Deep, G. (2019). Syntaxin 6: A novel predictive and prognostic biomarker in papillary renal cell carcinoma. Scientific Reports. 9 (1): 3146.

13. Christensen, B.J., Chapple, A.G., King, B.J. (2019). What is the Effect of Treating Mandibular Fractures on Weight and Prealbumin? Journal of Oral and Maxillofacial Surgery. 77 (6): 1-6.

14. Chapple, A.G., Blackston, J.W. (2019). Finding benefit in n-of-1 trials. JAMA Intern Med. 179(3):453-454.

15. Peak, T. C., Russell, G. B., Dutta, R., Rothberg, M. B., Chapple, A. G. and Hemal, A. K. (2019). A National Cancer Database-based nomogram to predict lymph node metastasis in penile cancer. BJU International. 123: 1004-1010. 10.1111/bju.14652

16. Chapple, A. G. and Thall, P. F. (2019). Rejoinder to “A hybrid phase I‐II/III clinical trial design allowing dose reoptimization in phase III”. Biometrics.

17. Simkin, J., Bronstone, A., Chapple, A., Clement, R.C., Cohen-Rosenblum, A., Czarny-Ratajczak, M., Dasa, V. Hilliard, C., King, A., Krause, P., and Marrero, L. (2019). Letter to the Editor: Editorial: Beware of studies claiming that social factors are “independently associated” with biological complications of surgery. Clinical Orthopedics and Related Research. 477 (12): 2807-2809

18. Blackston, J.W., Chapple, A.G., McGree, J.M., McDonald, S.N., Nikles, J (2019). Comparison of aggregated N-of-1 trials with parallel and crossover randomized controlled trials using simulation studies. Healthcare, 7, 137.

19. Chapple, AG, Peak, T, Hemal, A. A novel Bayesian continuous piecewise linear log‐hazard model, with estimation and inference via reversible jump Markov chain Monte Carlo. Statistics in Medicine. 2020; 1– 15. https://doi.org/10.1002/sim.8511

20. Cameron JE, Dennis DC, Herrel NR, Chapple AG, and Hagensee ME. (2020) Risk of abnormal cervical cytology in HIV-infected women testing positive for both human papillomavirus and Epstein-Barr virus in genital tract specimens. Cancer Causes and Control. 31(4):365-375.

21. Chapple, A.G. (2020). Bayesian subgroup clustering in phase I clinical trials. SAGE Research Methods Cases. doi: https://dx.doi.org/10.4135/9781529742657

22. Silver V, Chapple A, Feibus A, Beckford J, Halapin N, Delphi B, Gordon A, Baumgartner W, Vignes S, Clark C, Kambok S, Lim S, Mackey S, Seal P, Kanter J, Bell C, Clement M. Clinical Characteristics and Outcomes Based on Race of Hospitalized Patients with COVID-19 in a New Orleans Cohort. Accepted for publication, Open Forum Infect Dis.

23. Chapple, A. G., & Thall, P. F. (2020). Comparison of Phase I-II designs with parametric or semi-parametric models using two different risk-benefit trade-off criteria. Contemporary clinical trials, 97, 106099. https://doi.org/10.1016/j.cct.2020.106099

24. Block MS, Christensen BJ, Mercante D, Chapple AG. (2020). What factors are associated with implant failure? Journal of Oral and Maxillofacial Surgery. https://doi.org/10.1016/j.joms.2020.08.023

25. Pratt, A., Scheinuk, J., Lopez, D., Mesa, C. J., Mahato, S., Chapple, A. G., & Guevara, M. E. (2020). Sunscreen knowledge amongst rheumatologists: Finding the gap. Lupus. 30(2):360-362. https://doi.org/10.1177/0961203320973272

26. LeMoine F, Moore RC, Chapple A, Moore FA, Sutton E. (2020) Neonatal Survivability following Previable PPROM after Hospital Readmission for Intervention. AJP Rep. Oct; 10(4):e395-e402. doi: 10.1055/s-0040-1721421. Epub 2020 Dec 3. PMCID: PMC7714616

27. Hoffseth KF, Simkin J, Busse E, Stewart K, Watt J, Chapple A, Hargrove A, Sammarco MC. (2020) A New Approach to Analyzing Regenerated Bone Quality in the Mouse Digit Amputation Model using Semi-automatic Processing of microCT Data. Bone. 2020 Dec 1:115776. doi: 10.1016/j.bone.2020.115776 PMID: 33276153.

28. McDougal, M., Nair-Fairless, P., Weiss, T., Dao, E., Chapple, A. G., & Jernigan, A. (2021). Practice patterns and results of tumor and germline genetic evaluation of women with endometrial cancer in south Louisiana. Gynecologic oncology reports, 36, 100717. https://doi.org/10.1016/j.gore.2021.100717

29. Salomon, B., Krause, P. C., Dasa, V., Shi, L., Jones, D., & Chapple, A. G. (2021). The Impact of Hepatitis C and Liver Disease on Risk of Complications After Total Hip and Knee Arthroplasty: Analysis of Administrative Data From Louisiana and Texas. Arthroplasty today, 7, 200–207. https://doi.org/10.1016/j.artd.2020.12.016

30. Johnson, K. D., Akingbola, O., Anderson, J., Hart, J., Chapple, A., Woods, C., Yeary, K., & McLean, A. (2021). "Combating a “Twin-demic”: A Quantitative Assessment of COVID-19 and Influenza Vaccine Hesitancy in Primary Care Patients". Health Promotion perspectives. https://hpp.tbzmed.ac.ir/PDF/hpp-34133

31. Buzhardt, S, Chapple, AG, LeMoine, F, McCune, K, Moore, F, Sutton, E (2021). Surgical Site Infection Risk in Cesarean Delivery Patients with Obesity Following Negative Pressure Wound Therapy: A Retrospective Cohort Study. Surgery. https://doi.org/10.1016/j.surg.2021.02.056

32. Salomon, B, Krause, P.C., Dasa, V., Hall, L., Shi, L., Chapple, AG (2021). Hospital length of stay is associated with increased likelihood for venous thromboembolism following total joint arthroplasty. Arthroplasty today. https://doi.org/10.1016/j.artd.2020.12.025