Education

2009: Ph.D. in Neurosciences, Louisiana State University Health, New Orleans, School of Graduate Studies.  

2002: Licenciada en Ciencias Biologicas, area Neurobiologia Molecular

Equivalent: Bachelor in Biological Sciences and Master degree in Molecular Biology and Neuroscience.

Facultad de Ciencias Exactas y Naturales, UBA, Buenos Aires Argentina.

1992: Analytical Chemistry Technical degree: National Technical School ENET Nº 27 Hipolito Yrigoyen, Buenos Aires. Argentina.

Selected Publications

• Calandria JM, Bhattacharjee S, Maness NJ, Kautzmann MI, Asatryan A, Gordon WC, Do KV, Jun B, Mukherjee PK, Petasis NA, Bazan NG. 2022. Elovanoids downregulate SARS-CoV-2 cell-entry, canonical mediators and enhance protective signaling in human alveolar cells. Sci Rep. 11(1):12324. PMID: 34112906

• Rugolo F, Bazan NG, Calandria J, Jun B, Raschellà G, Melino G, Agostini M. 2021. The expression ELOVL4, repressed by MYCN, defines neuroblastoma patients with good outcome. Oncogene. 40(38):5741-5751. PMID: 34333551

• Calandria JM, Sharp MW, Bazan NG. 2015. The Docosanoid Neuroprotectin D1 Induces TH-Positive Neuronal Survival in a Cellular Model of Parkinson's Disease. Cell Mol Neurobiol. 35(8):1127-36. PMID: 26047923.
• Belayev L, Mukherjee PK, Balaszczuk V, Calandria JM, Obenaus A, Khoutorova L, Hong SH, Bazan NG. Neuroprotectin D1 upregulates Iduna expression and provides protection in cellular uncompensated oxidative stress and in experimental ischemic stroke.  Cell Death Differ. 2017 Jun;24(6):1091-1099.
• Rice DS, Calandria JM, Gordon WC, Jun B, Zhou Y, Gelfman CM, Li S, Jin M, Knott EJ, Chang B, Abuin A, Issa T, Potter D, Platt KA, Bazan NG. Adiponectin receptor 1 conserves docosahexaenoic acid and promotes photoreceptor cell survival. Nat Commun. 2015 Mar 4;6:6228. doi: 10.1038/ncomms7228. Erratum in: Nat Commun. 2015;6:7225.
• Calandria JM, Asatryan A, Balaszczuk V, Knott EJ, Jun BK, Mukherjee PK, Belayev L, Bazan NG. 2015. NPD1-mediated stereoselective regulation of BIRC3 expression through cREL is decisive for neural cell survival. Cell Death Differ. 22(8):1363-77. PMID: 25633199
   
• Calandria JM, Mukherjee PK, de Rivero Vaccari JC, Zhu M, Petasis NA, Bazan NG. Ataxin-1 poly(Q)-induced proteotoxic stress and apoptosis are attenuated in neural cells by docosahexaenoic acid-derived neuroprotectin D1. J Biol Chem. 2012 Jul 6;287(28):23726-39. PMID: 22511762
   
• Calandria JM, Marcheselli VL, Mukherjee PK, Uddin J, Winkler JW, Petasis NA, Bazan NG. 2009 Selective Survival Rescue in 15-Lipoxygenase-1-deficient Retinal Pigment Epithelial Cells by the Novel Docosahexaenoic Acid-derived Mediator, Neuroprotectin D1. J Biol Chem. 284:17877-82. PMCID: PMC2719426
   
• Tafet GE, Idoyaga-Vargas VP, Abulafia DP, Calandria JM, Roffman SS, Chiovetta A, Shinitzky M. Correlation between cortisol level and serotonin uptake in patients with chronic stress and depression. Cogn Affect Behav Neurosci. 1:388-393, 2001. PMID: 12467090
   
• Alperin MD, Calandria JM, Carminatti H, Idoyaga-Vargas VP. Altered protein mannosylation in developing cerebral cortex by streptomycin. Neuroreport11:3569-3572, 2000. PMID: 11095520

Complete List of Published Work in My Bibliography: https://www.ncbi.nlm.nih.gov/myncbi/jorgelina.calandria.1/bibliography/public/

Research Interests

My interests are centered in the mechanisms of neuroprotection exerted by bioactive lipids derived from docosahexaenoic acid (DHA). We focus on age-related neurodegenerative and other pathologies related with dopamine neuronal systems, for instance, Parkinson’s disease and Lewy body dementia, seeking to counteract the effects of dysregulated phospholipase A2 group VI. For this purpose, we utilize an acute and a chronic rat model of Parkinsonian disorders with bioactive lipids. Of special interest are the effects of lipid mediators targeting microglia and astrocytes and their transformation into pro-survival phenotypes.