|
Keywords Associated with Work
Epigenetics
|
|
Intermittent hypoxia
|
|
Neuroprotection
assessed functionally and morphologically
|
|
Retinal Diseases
neuroprotection
|
|
Stroke
neuroprotection
|
|
Primary Research / Clinical / Teaching Interests
Retinal Diseases
epigenetic approaches to retinal protection - mechanisms and therapeutics
mouse models of glaucoma and other retinopathies
|
|
Secondary Research / Clinical / Teaching Interests
Stroke
epigenetic approaches to neurovascular protection - mechanisms and therapeutics
mouse models of stroke
|
|
Unique Equipment Used
In vivo studies in mouse models of retinal degenerative diseases
We use a variety of experimental approaches in our studies, including in vivo functional and structural assessments of retinal physiology by ERG and OCT, respectively. Immunohistochemistry, other molecular biological methods employed in wild-type and mutant mice.
|
|
Unique Techniques Used or Developed
stress conditioning (hypoxia) as a neuroprotective therapeutic for retinal disease
using systemic hypoxia as an epigenetic stimulus for neuroprotection in glaucoma and other neurodegenerative diseases of the retina
Using functional and structural metrics of retinal injury/protection by electroretinography and optical coherence tomography
mechanisms of transgenerational epigenetics; DNA methylation and bioinformatic analyses
|
