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David Lefer, PhD
School of Medicine
Pharmacology / Cardiovascular Center of Excellence
Grant Review Committees Served on: NIH Other Committees

Primary Research / Clinical / Teaching Interests:
	Cardiovascular Pathology Cardiovascular Physiology Hydrogen Sulfide Signaling Nitric Oxide Signaling Renal Denervation Translational Research
Secondary Research / Clinical / Teaching Interests:
	Antioxidant Therapy Fibrosis Metabolomics Mitochondria, Heart Neprilysin

Unique Techniques Used or Developed:
	Hydrogen Sulfide Measurement by Gas Chromatography Chemiluminescence Model - Mouse Myocardial Infarct Induced Heart Failure Model - Mouse Myocardial Ischemia Reperfusion Injury Model - Mouse Transaortic Constriction (TAC) Left Ventricular Hypertrophy Model - Rat Myocardial Infarct Induced Heart Failure Model - Rat Myocardial Ischemia Reperfusion Injury Model - Swine Myocardial Infarct Induced Heart Failure Model - Swine Myocardial Ischemia Reperfusion Injury Nitrite/Nitric Oxide Metabolite Measurement by Ion Chromatography
Unique Equipment Used:
	Ex Vivo Vascular Reactivity Radnoti Organ Bath Chambers (16)Gas Chromatography Chemiluminescence for Plasma and Tissue Hydrogen Sulfide Ion Chromatography (ENO20 Analyzer, Eicom) for Plasma and Tissue Nitrite Li-Cor Odyssey CLx Imaging System Microsurgical Procedural Stations (10) for Mice Millar Pressure Catheter/Hemodynamic Systems for Mice Millar Pressure Catheter/Hemodynamic Systems for Rats Surgical Procedural Stations (5) for Rats Visual Sonics Vivo 2100 for Mice Visual Sonics Vivo 2100 for Rats Visual Sonics Vivo 2100 Workstations (3)
Keywords Associated with Work:
	Cardiovascular Agents Cardiovascular Physiological Processes Cardiovascular System Diabetes Mellitus, Experimental Heart Failure Hydrogen Sulfide Metabolic Syndrome X Models, Cardiovascular Myocardial Ischemia Myocardial Reperfusion Injury Nitric Oxide Nitric Oxide Donors Nitric Oxide Synthase Nitrite Reductases Prostaglandin Antagonists Renal Denervation Simvastatin Sodium Nitrite Statin Therapy Transaortic Constriction (TAC) Mouse Model

Last Updated: 11/13/2019