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Faculty Interests Database

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David Lefer, PhD
School of Medicine
Pharmacology / Cardiovascular Center of Excellence
Grant Review Committees Served on:   NIH     Other Committees  
Primary Research / Clinical / Teaching Interests:
Cardiovascular PathologyCardiovascular PhysiologyHydrogen Sulfide SignalingNitric Oxide SignalingRenal DenervationTranslational Research
Secondary Research / Clinical / Teaching Interests:
Antioxidant TherapyFibrosisMetabolomicsMitochondria, HeartNeprilysin
Unique Techniques Used or Developed:
Hydrogen Sulfide Measurement by Gas Chromatography ChemiluminescenceModel - Mouse Myocardial Infarct Induced Heart FailureModel - Mouse Myocardial Ischemia Reperfusion InjuryModel - Mouse Transaortic Constriction (TAC) Left Ventricular HypertrophyModel - Rat Myocardial Infarct Induced Heart FailureModel - Rat Myocardial Ischemia Reperfusion InjuryModel - Swine Myocardial Infarct Induced Heart FailureModel - Swine Myocardial Ischemia Reperfusion InjuryNitrite/Nitric Oxide Metabolite Measurement by Ion Chromatography
Unique Equipment Used:
Ex Vivo Vascular Reactivity Radnoti Organ Bath Chambers (16)Gas Chromatography Chemiluminescence for Plasma and Tissue Hydrogen SulfideIon Chromatography (ENO20 Analyzer, Eicom) for Plasma and Tissue NitriteLi-Cor Odyssey CLx Imaging SystemMicrosurgical Procedural Stations (10) for MiceMillar Pressure Catheter/Hemodynamic Systems for MiceMillar Pressure Catheter/Hemodynamic Systems for RatsSurgical Procedural Stations (5) for RatsVisual Sonics Vivo 2100 for MiceVisual Sonics Vivo 2100 for RatsVisual Sonics Vivo 2100 Workstations (3)
Keywords Associated with Work:
Cardiovascular AgentsCardiovascular Physiological ProcessesCardiovascular SystemDiabetes Mellitus, ExperimentalHeart FailureHydrogen SulfideMetabolic Syndrome XModels, CardiovascularMyocardial IschemiaMyocardial Reperfusion InjuryNitric OxideNitric Oxide DonorsNitric Oxide SynthaseNitrite ReductasesProstaglandin AntagonistsRenal DenervationSimvastatinSodium NitriteStatin TherapyTransaortic Constriction (TAC) Mouse Model
Last Updated: 11/13/2019