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FACULTY

Michael Hagensee

Professor
Vice Chair of Research, Department of Medicine

Infectious Disease

Academic Office:

LSUHSC School of Medicine 
1700 Tulane Ave, Room 602
New Orleans, LA 70112

504-210-3325

 

Clinical Office:

Ochsner Medical Center
1514 Jefferson Hwy.
New Orleans, LA 70121

866-624-7637

 

Bio

Over the 25 years that I have been at LSUHSC, my research focus has been examining human papillomavirus (HPV) infection of HIV+ and HIV-negative individuals and the body’s immune response against HPV.  I have been successful in obtaining funding from many different sources including the National Institutes of Health, American Cancer Society, Doris Duke Research Foundation and the Centers for Disease Control. In addition, I have had the opportunity to be the site Principle Investigator for a number of HPV treatment and diagnostics studies, studies to prevent anal cancer and more recently studies focused on those afflicted by COVID-19.  Over the years at LSUHSC, I have had many mentoring experiences at many levels. I have directly mentored 5 PhD students, 4 Master’s students, numerous summer research students and a number of junior faculty in formal and more informal ways. On a clinical note, I am a board-certified Infectious Disease provider who has had a primary care practice for HIV+ individuals for the past 25 years. I also perform inpatient consulting at University Medical Center, East and West Jefferson General Hospitals, Touro Infirmary and Kenner Regional Hospital. I have been on the New Orleans Best Doctor's list for 15 years with a featured article in 2015.  I have served on the Institutional review Board for over 15 years and on the Promotion and Tenure Committee for 10 years. I served as chair of P and T committee for 2 years ending in 2020.    

Education

Undergraduate:
19980 - B.S.
University of Illinois
Champaign County, Illinois

Graduate:
1986 - Ph.D. in Cell Biology
Baylor College School of Medicine
Houston, Texas

Medical:
1988 - M.D.
Baylor College School of Medicine
Houston, Texas

Residency:
1988-1991 - Internal Medicine
University of Washington Affiliated Hospitals
Seattle, Washington 

Fellowship:
1991-1994 - Infectious Diseases
University of Washington Affiliated Hospitals
Seattle, Washington 

Affiliated Hospitals & Clinics

  • University Medical Center
  • East Jefferson General Hospital
  • Ochsner Kenner Medical Center
  • Touro Infirmary
  • West Jefferson Medical Center

Publications

1. Chesson HW, Flagg EW, Koutsky L, Hsu K, Unger ER, Shlay JC,  Kerndt P, Ghanem KG, Zenilman JM, Hagensee ME, Weinstock H, Datta SD.  Modeling the impact of quadrivalent HPV vaccination on the incidence of Pap test abnormalities in the United States.  Vaccine 2013 May 9.31: 3019-24

2. Crosby RA1, Hagensee ME, Vanderpool R, Nelson N, Parrish A, Collins T, Jones N Community-Based Screening for Cervical Cancer: A Feasibility Study of Rural Appalachian Women. Sex Transm Dis. 2015 Nov;42(11):607-11

3. Dehon PM, Hagensee ME, Sutton KJ, Oddo HE, Nelson N, McGowin CL.  Histological Evidence of Chronic Mycoplasma genitalium-Induced Cervicitis in HIV-Infected Women: A Retrospective Cohort Study.  J Infect Dis. 2016 Jun 1;213(11):1828-35.  PMID: 26783349

4. Donna L. Williams, Michael Hagensee, Ruijuan Gao, Danny Barnhill, Elizabeth T. H. Fontham The accuracy and validity of HPV testing through self-collection with tampons for cervical cancer screening. Transl Cancer Res 2016;5(Suppl 5):S9930-S999

5. Crosby, RA, Hagensee, ME, Fisher, R, Stradtman, LR and Collins, T.  Self-collected vaginal swabs for HPV screening: An exploratory study of rural Black Mississippi women.   Prev Med Rep 2016 Dec 23; 7:227-231

6. Williams, DL, Wheeler, CS, Lawrence M, Hall, SS and Hagensee, M. Louisiana Physicians are Increasing HPV Vaccination Rates.  J LA State Med Soc 2017 May-Jun; 169(3) 63-67.

7. Ware, SL, Crosby R., Fisher, R and Hagensee ME.  Human Papillomavirus Prevalence is Associated with Socioeconomic Gradients within a Medically Underserved Appalachian Region.  Sex Transm Dis 2017 Dec; 44(12): 750-755.

8. Cameron, JE,  Rositch, A, Vielot, N, Mugo, NR, Kwatampora, J,Waweru, W, Gilliland, AE, Hagensee, ME, and Smith, JS.  Epstein-Barr virus, high-risk human papillomavirus and abnormal cervical cytology in a prospective cohort of African female sex workers.  Sex Transm Dis 45 (10): 666-672.  2018.  PMID: 29664764

9.Cervical Human Papillomavirus Testing With Two Home Self-Collection Methods Compared With a Standard Clinically Collected Sampling Method. McLarty JW, Williams DL, Loyd S, Hagensee ME. Sex Transm Dis. 2019 Oct;46(10):670-675. PMID: 31517806

10. Significant effect of HIV/HAART on oral microbiota using multivariate analysis. Griffen AL, Thompson ZA, Beall CJ, Lilly EA, Granada C, Treas KD, DuBois KR 3rd, Hashmi SB, Mukherjee C, Gilliland AE, Vazquez JA, Hagensee ME, Leys EJ, Fidel PL Jr. Sci Rep. 2019 Dec 27;9(1):19946. doi: 10.1038/s41598-019-55703-9. PMID: 3188258.

11. Cameron JE, Dennis DC, Herrel NR, Chapple AG, and Hagensee ME. Risk of abnormal cervical cytology in HIV-infected women testing positive for both human papillomavirus and Epstein-Barr virus in genital tract specimens. Cancer Causes and Control 020 Apr;31(4):365-375. PMID: 32112173.

12. Interplay between oral immunity in HIV and the microbiome. Fidel PL Jr, Moyes D, Samaranayake L, Hagensee ME. Oral Dis. 2020 Sep;26 Suppl 1(Suppl 1):59-68. PMID: 32862522

13. Association of Diet Quality and Dietary Components with Clinical Resolution of HPV. Naresh A, Hagensee M, Myers L, Cameron J. Nutr Cancer. 2020 Oct 29:1-10. PMID: 33121274

14. Antioxidants Associated with Oncogenic HPV Infection in women. Lin HY, Fu Q, Kao YH, Tseng TS, Reiss K, Cameron JE, Ronis MJ, Su J, Nair N, Chang HM, Hagensee ME. J Infect Dis. 2021 Mar 18:jiab148.PMID: 33735375.

15. Effect of HIV/HAART and Other Clinical Variables on the Oral Mycobiome Using Multivariate Analyses. Fidel PL Jr, Thompson ZA, Lilly EA, Granada C, Treas K, Dubois KR 3rd, Cook L, Hashmi SB, Lisko DJ, Mukherjee C, Vazquez JA, Hagensee ME, Griffen AL, Leys EJ, Beall CJ. mBio. 2021 Mar 23;12(2):  PMID: 3375809.

View FUll List of PUblications

Research

Title: Use of a live attenuated vaccine repurposed as an innate immune-based preventive against COVID-19-associated sepsis/inflammation PF 1214  
Sponsor: Parsemus Foundation
Role: Investigator, (PI:Fidel)
Dates: 8/1/20 – 12/31/21

Title: Use of an unrelated live attenuated vaccine as an innate immune-based preventive against COVID-19-associated sepsis/inflammation
Sponsor: Fast Grants #2179, Emergent Ventures at the Mercatus Center, George Mason University
Role: Investigator, (PI: Fidel)
Details: MMR/Placebo randomized clinical trial for the induction of myeloid-derived suppressor cells (MDSCs) and health status +/- COVID infection. Trial is specified for 150 subjects, 75 subjects/arm.
Dates: 09/05/20 – 09/04/22

Title: Utilizing Quantitative COVID-19 Serological Testing to Determine Current Immune status and Predict Future Protection
Sponsor: LSU School of Medicine
Dates: 10/07/20 – 10/06/21

Title: AIDS Malignancy Consortium. AMC-088.
Sponsor: NCI
Role: Site Principle Investigator
Details: A Randomized, Phase III Study of Intra-anal Imiquimod 2.5% vs. Topical 5-fluorouracil 5% vs. Observation for the Treatment of High-grade Anal Squamous Intraepithelial Lesions in HIV-infected Men and Women – enrolled 4 subjects 
Dates: 10/16 – 10/19 

Title: ANCHOR (Anal Cancer/HSIL Outcome Research Study) 
Sponsor: NCI
Role: Local Principle Investigator, (Palefsky – PI)
Details:This is to be a study site for the multi-site study to determine if treating high-grade anal lesions leads to lower anal cancer rates.
Dates: 2014 – 2019   

Title: Predictors of cervical dysplasia in HIV-infected women
Sponsor: Doris Duke Clinical Research Scientist
Role: Principle Investigator
Details:Examination of the local cervical immunity against HPV as a predictor of cervical dysplasia. 
Dates: 7/1/98 - 6/30/01

Title: Non-invasive detection of antibodies against HPV
Sponsor: NIH
Role: Principle Investigator
Details: Detection of HPV antibodies from saliva and comparison to serum. 
Dates: 4/15/99 – 3/30/01

Title: Development of a primate model of HPV infection, start up funds for 6 animals
Sponsor: Tulane Regional Primate Center
Role: Principle Investigator
Details: Study to attempt to cervically infect primates with Human Papillomavirus. 
Dates: 1/1/00 – 12/31/02

Title: Development of a urine PCR assay for HPV DNA detection
Sponsor: NIH - National Cancer Institute. 5R03CA111327-02
Role: Principle Investigator
Details: Studies to develop the ability to detect HPV DNA from urine and comparisons to simultaneous cervical samples.
Dates: 4/1/00 – 3/31/02

Title: Prevalence of serum antibodies against HPV capsid antigens as a marker for cervical cancer
Sponsor: American Cancer Society
Role: Principle Investigator
Details: Detection of human papillomavirus from stored serum of pregnant women from the 1980s and comparison to a modern cohort  
Dates: 7/1/00 – 6/30/03

Title: Interaction of EBV and HPV in the Development of Cervical Dysplasia in HIV+ women, RO1
Sponsor: National Cancer Institute
Role: Principle Investigator
Details: This study is to explore an interaction between EBV and HPV that leads to an increase in cervical dysplasia. 1R01CA121979-01. $1,979,254.  
Dates: 5/1/08 – 4/30/13

Title: Dillard-LSUHSC Minority Health and Health Disparities Research Center
Sponsor: NIH/NIMHD
Role: Investigator, (PIs - Dennis, Estrada)
Dates: 05/16/2010 – 02/28/2011

Title: The oral microbiome in HIV-associated oral warts and candidiasis
Sponsor: NIH/NIDCR
Role: Co-Investigator, (Fidel, Leys, Griffen)
Dates: 10/1/13 – 9/30/18