Karen Weissbecker
Publications

ORIGINAL ARTICLES IN REFERRED JOURNALS

  1. Wolf, B., Heard, G.S., Jefferson, L.G., Proud, V.K., Nance, W.E., and Weissbecker, K.A.: Clinical Findings in four children with biotinidase deficiency detected through a statewide neonatal screening program. New Eng. J. Med. 313:16-19, 1985.
  2. Wolf, B., Heard, G.S., Weissbecker, K.A., McVoy, J.R.S., Grier, R.E., and Leshner, R.T.: Biotinidase deficiency:  Initial clinical features and rapid diagnosis.  Annals of Neurology 18:614-617, 1985.
  3.  Heard, G.S., Wolf, B., Jefferson, L.G., Weissbecker, K.A., Nance, W.E., Napolitano, A., Mitchell, P.L., Lambert, F.W., and  Linyear,  A.S.:  Newborn screening for biotinidase deficiency: Results of a one-year pilot study.  J. Pediatr. 108(1):40-46, 1986.
  4. Wolf, B., Heard, G.S., Jefferson, L.G., Weissbecker, K.A., McVoy, J.R.S., Nance, W.E., Mitchell, P.L., Lanbert, F.W., and Linyear, A.S.: Neonatal screening for biotinidase deficiency; An update.  J.Inher.Metab.Dis. 9 (Suppl.) 2:303-306, 1986.
  5. Burton, B.K., Roach, E.S., Wolf, B., Weissbecker, K.A.: Sudden death associated with biotinidase deficiency.  Pediatrics. 78(3):482-483, 1987.
  6. O� Hanlon, K., Weissbecker, K.A., Cortessis, V., Spence, M.A., and Azen, E.A., Genes for salivery proline-rich proteins and taste for phenylthiourea are not closely linked in humans. Cytogenet. and Cell Genet., 49:315-317, 1988.
  7. Weissbecker, K.A., Gruemer, H-D., Heard, G, Miller, G., Nance, W.E., and Wolf, B.: An automated system for analyzing biotinidase activity in human serum. Clin. Chem. 35(5):831-833, 1989.
  8. Delgado-Escueta, A.V., Greenberg, D., Weissbecker, K.A., Liu, A. Treiman, L., Sparkes, R., Park M.S., Barbetti, A., and Terasaki, P.I.: Gene mapping in the idiopathic generalized epilepsies: Juvenile myoclonic epilepsy, childhood absence epilepsy, epilepsy with grand mal seizures, and early childhood myoclonic epilepsy.  Epilepsia, 31(S3):19-29, 1990.
  9. Weissbecker, K.A., Durner, M., Scaramelli, A., Janz, D., Sparkes, R.S. and Spence, M.A.: Confirmation of linkage between Juvenile Myoclonic Epilepsy and the HLA region of chromosome 6., Am. J. Med. Genet., 38:32-36, 1991
  10. Delgado-Escueta, A.V., Greenberg, D., Weissbecker, K.A., Serratosa, J.M., Liu, A., Treiman, L., Sparkes, R., Park M.S., and Barbetti, A.: The choice of epilepsy syndromes for genetic analysis. Epilepsy Res Suppl, 4:147-159, 1991.
  11. Smith, M.L., Pellett, O.L., Cahill, T.C., David, D.N., Kaskel, F.J., Smolin, L.A., Greene, A.A., Weissbecker, K.A., Dean, M., and Schneider, J.A.: Biochemical and Genetic analysis of a Child with Both Cystic Fibrosis and Cystinosis., Am. J. Med. Genet., 39:84-90, 1991.
  12. Weissbecker, K.A., Wolf, B., Eaves, L.J. and Nance, W.E.:  Statistical approaches for the detection of heterozygotes for biotinidase deficiency, Am. J. Med. Genet. 39:385-390, 1991.
  13. Nicolini H, Weissbecker K, Baxter L, Hanna G, Spence MA. Segregation analysis of obsessive compulsive and related disorders; preliminary results.  Ursus Medicus Journal 1:25-28, 1991.
  14. Nicolini, H., Weissbecker, K.A., Mejia, J.M., and S�nchez de Carmona, M.: Family study of Obsessive-compulsive Disorder in a Mexican population.  Archives of Medical Research 24:193-198, 1993.
  15. Weissbecker, K.A., Wolf, B., Eaves, L.J., Marazita, M., and Nance, W.E.: Combined pedigree and twin family study to determine the sources of variation in serum biotinidase activity: The usefulness of multiple study designs.  Am. J. Med. Genet. 47:231-240, 1993.
  16. Weissbecker, K.A.: Segregation analysis of diastolic blood pressure in a large pedigree. Genet. Epidemiology. 10:659-664, 1993.
  17. Delgado-Escueta, A.V., Serratosa, J.M., Lui, A., Weissbecker, K.A., Medina, M.T., Gee, M, Treiman, L.J., and Sparkes, R.S.: Progress in mapping epilepsy genes. Epilepsia 35(S1):29-40,1994.
  18. Nicolini, H., Cruz, C., Camerena, B., Orozco, B., Kennedy, J.L., King, N., Weissbecker, K.A., De la Fuente, JR.and Sidenberg, D: DRD2 , DRD3 and 5HT2A receptor genes polymorphisms in Obsessive-Compulsive Disorder. Molecular Psychiatry 1:461-465, 1996.
  19. Korczak, J.F., Bergen, A.W., Goldstein, A.M., and Weissbecker, K.A.: Sib-pair linkage analysis of alcoholism: Dichotomous and quantitative measures. In: Goldin L, Amos CI, Chase GA, Goldstein AM, Jarvik GP, Martinez MM, Suarez BK, Weeks DE, Wijsman EM, and MacCluer JW. Genetic Analysis Workshop 11: Analysis of genetic and environmental factors in common diseases. Genetic Epidemiology, 17:S205-S210, 1999.
  20. Bergen, A.W., Korczak, J.F., Weissbecker, K.A., and Goldstein, A.M.: A genome-wide search for loci contributing to smoking and/or alcoholism. In: Goldin L, Amos CI, Chase GA, Goldstein AM, Jarvik GP, Martinez MM, Suarez BK, Weeks DE, Wijsman EM, and MacCluer JW. Genetic Analysis Workshop 11: Analysis of genetic and environmental factors in common diseases.Genetic Epidemiology, 17:S55-S60, 1999.
  21. Townsend, M.H., Weissbecker, K.A.,Barbee, J., Pena, JM., Snider, LM,  Tynes, LL, Tynes, S. Boudoin, C., Green-Leibovitz, MI, and Winstead, D.: Compusive Behavior in General Anxiety Disorder and Obsessive Compulsive Disorder. J Nervous and Mental Disease 187(11):697-699,1999.
  22. Mandal, D.M., Wilson, A.F., Elston, R.C., Keats, B.J., Weissbecker, K.A., and Bailey-Wilson, J.E.: Effect of misspecification of allele frequencies on the type I error of model free linkage analysis using computer simulation. Human Heredity 50(2):126-132, 2000
  23. Narayan, A., Tuck-Muller, C., Weissbecker, K., Smeets, D., and Ehrlich, M.: Hypersensitivity to radiation-induced non-apoptotic and apoptotic death in cell lines from patients with the ICF chromosome instability syndrome. Mutation Research 456:1-15, 2000.
  24. Bailey-Wilson, J.B.,  Sorant, A.J.M, Malley, J. D., Presciuttini, S, Redner, R.A., Severini, T.A, Badner, J.A., Pajevic, S., Jufer, R., Baffoe-Bonnie, A, Kao,  L,  Doan, B.Q.,  Goldstein , J, Holmes,  T.N., D Behnemann, D., Mandal, D.M., Turley , T., Weissbecker, K.A.,  O�Neill, J., Pugh, B.W. Comparison of novel and existing methods for detection of linkage disequilibrium using parent-child trios in the GAW12 genetic isolate simulated data. In Wijsman EM, Almasy L, Amos CI,  et al. (2001).  Analysis of complex genetic traits: Applications to asthma and simulated data. In Genetic Epidemiology, Volume 21(Suppl 1), pgs. S1-S853, 2001.
  25. Tsien, F., Fiala, E.S., Youn, B., Long, T.I., Laird, P.W., Weissbecker, K., and Ehrlich, M. Prolonged culture of normal chorionic villus cells yields ICF syndrome-like chromatin decondensation and rearrangements. (submitted to Cytogenetics and Genome Research)
  26. Morava, E., Weissbecker, K., Czako, M., Hadzsiev, K., Kosztolanyi, G., and Mehes, K. Autosomal dominate ulnar/fiular ray defect: a possible new syndrome. (submitted to: Journal of Clinical Dysmorphology)
  27. Weissbecker, K., O�Conner, J.B., Pe�a, JM., Snider, LM, Tynes, LL, Tynes, S , Boudoin, C , Green-Leibovitz, MI, and Winstead, DK: Effect Of Co-Morbid Major Depression On Symptoms And Familial Aggregation Of Obsessive Compulsive Disorder. (in preparation)

 

ARTICLES IN NON-REFERRED JOURNALS

  1. Weissbecker, K.A., Lacassie, Y.,  Thomas, I.T.: Neurofibromatosis type 1.  Children�s Hospital Pediatric Review XI (1):1-3, 1997.
  2. Weissbecker, K.A., Lemelle, T., Deeney, T, and Lacassie, Y.: Clinical Variability of Neurofibromatosis type 1.  Children�s Hospital Pediatric Review XV (10) 1-3, 2001.

 

BOOK CHAPTERS

  1. Wolf, B., Heard, G.S., Jefferson, L.G., Weissbecker, K.A., McVoy, J.R.S., Nance, W.E., Mitchell, P.L., Lanbert, F.W., and Linyear, A.S.: Newborn screening for biotinidase deficiency.  In Genetic Diseases:  Screening and Management, Alan R. Liss, New York, N.Y., 1986.
  2. Delgado-Escueta, A.V., Greenberg, D., Weissbecker, K.A., Serratosa, J.M., Liu, A., Treiman, L., Sparkes, R., Park M.S., Barbetti, A., and Terasaki, P.I.: The choice of epilepsy syndromes for genetic analysis. In Genetic Strategies in Epilepsy Research , ed. by Anderson, V.E., Hauser, W.A., Leppik, T.E. Nobels, J.L., Rich, S.S., Elsevier Science Publications, pp.143-155, 1991.
  3. Weissbecker, K.A., Elston, R.C., Greenberg, D.A., and Delgado-Escueta, A.V. : Genetic epidemiology and the search for epilepsy genes., In  Jasper�s Basic Mechanisms of the Epilepsies, Third edition,  Advances in Neurology, Vol 79, ed. by A.V. Delgado-Escueta,  W. Wilson, R.W. Olsen, and R.J. Porter, Lippincott Williams and Wilkins, Philidelphia, pp.323-340, 1999.
  4. Delgado-Escueta, A.V., Medina, M.T., Serratosa, J.M., Castroviejo, I.P., Gee, M.N., Weissbecker, K.A., Westling, B, et al.: Mapping and positional cloning of common idiopathic generalized epilepsies: Juvenile myoclonic epilepsy and Childhood absence epilepsy. In  Jasper�s Basic Mechanisms of the Epilepsies, Third edition, Advances in Neurology, Vol 79, ed. by A.V. Delgado-Escueta,  W. Wilson, R.W. Olsen, and R.J. Porter, Lippincott Williams and Wilkins, Philidelphia, pp.351-374, 1999.


ABSTRACTS

  1. Franco, M., Weissbecker, K., Hartig, P.C., and Webb, S.R.: Strain selection of coxsackievirus B4 can overcome host resistance to virus-induced diabetes. Am. Microbio. Assoc., 1982.
  2.  Heard, G.S., Weissbecker, K.A., and Wolf, B.: A continuous flow procedure for determining biotinidase activity in serum.  Society for the Study of Inborn Errors of Metabolism, 22nd Symposium, 1984.
  3. Martin, N.G., Eaves, L.J., Mellon, B.G., Slaugh, R.A., Weissbecker, K.A.: Some problems with the generalized mixed model. Am. J. Hum. Genet. 36:174S (515), 1984.
  4. Weissbecker, K.A. Napolitano, A., Heard, G.S., and Wolf, B.: Implications of developmental changes in biotinidase activity for neonatal screening of biotinidase deficiency.  Am. J. Hum. Genet. 36:199S (591), 1984.
  5. Heard, G.S., Wolf, B. Jefferson, L.G., Weissbecker, K., Nance, W.E., Napolitano, A., Mitchell, P.L., Lambert, F.W., and Linyear, A.S.:  Results of a pilot newborn screening program for biotinidase deficiency.  Am. J. Hum. Genet. 37:A219 (649), 1985.
  6. Weissbecker, K.A., Wolf, B., Piussan, C., and Nance, W.E.: Detection of heterozygotes for biotinidase deficiency. Am. J. Hum. Genet. 37:A81 236), 1985.
  7. Wolf, B., Heard, G.S., Jefferson, L.G., Weissbecker, K.A., Nance, W.E., Mitchell, P.L., Lambert, F.W., and Linyear, A.S.: Neonatal screening for biotinidase deficiency. Society for the Study of Inborn Errors of Metabolism, 23rd Symposium, 1985.
  8. Wolf, B., Heard, G.S., Jefferson, L.G., Nance, W.E. and Weissbecker, K.:  Biotinidase deficiency detected by a statewide neonatal screening program.  Pediatric Research 19:256A (875), 1985.
  9. Weissbecker, K.A., Martin, N.G., Wolf, B. and Nance, W.E.:  Genetic and environmental contributions to variation in biotinidase activity. Int. Cong. Twin Studies 5:72, 1986.
  10. Spence, M.A., Weissbecker, K.A., Durner, M., Scaramelli, A., and Janz, D.: Linkage analysis of Juvenile Myoclonic Epilepsy and the HLA region. Am. J. Hum. Genet. 43:A159(634), 1988.
  11. Weissbecker, K.A., Wolf, B., Eaves, L., Marazita, M.L., and Nance, W.E.: Contributions of a major locus, polygenic and environmental effects to variation in biotinidase activity. Am. J. Hum. Genet., 43:A223(890), 1988.
  12. Weissbecker, K.A., Baxter, L., Schwartz, J., Sparkes, R.S. and Spence, M.A.:  Linkage analysis of obsessive compulsive disorder.  10th International Workshop on Human Gene Mapping, 1989.
  13. Weissbecker, K.A., Nance, W.E., Eaves, L.J., Puissan, C. and Wolf, B.:  Statistical methods for heterozygote detection: application to biotinidase deficiency., Am. J. Hum. Genet., 45:A12, 1989.
  14. Nicolini, H., Baxter, L., Hanna, G., Weissbecker, K.A., and Spence, M.A.: Segregation Analysis of Obsessive Compulsive Disorder., Am. J. Hum. Genet., 47:A141(0551), 1990.
  15. Nicolini, H., Weissbecker, K.A., Baxter, L., Hanna, G., and Spence, M.A.: Analisis de segregacion y mapeo cromosomico del trastorno obsesive compulsive.  XI Congreso Nacional de Psiquiatria.  Asociacion Psiquiatrica Mexicana, noviembre de 1989. Morelia, Mich, Mexico.
  16. Serratosa, J.M., Weissbecker, K.A., and Delgado- Escueta, A.V.: Childhood Absence Epilepsy: an       Autosomal Recessive Disorder?, Am. Epilepsy Society, 1990.
  17. Delgado-Escueta, A.V., Greenberg, D., Weissbecker, K.A., Serratosa, J., Abad-Herrera, P., Treiman,L., Liu, A., Sparkes, R.S., Park, M.S., and Terasaki, P.I.: Family Studies and the JME locus in 6p - Significance for CAE (Childhood Absence Epilepsy) and ECME (Early Childhood Myoclonic Epilepsy). International Conference on Genetics and Epilepsy, Minnesota, 1990.
  18. Serratosa, J.M., Delgado-Escueta, A.V., Weissbecker, K., Liu, A., Sparkes, R.S., and Treiman, L.J.: Family studies on childhood absence epilepsy (CAE). 43rd Annual meeting of the Amer. Acad. of Neurol., Neurol. 41:A128, 1991.
  19. Liu, A.W., Weissbecker, K.A., Delgado-Escueta, A.V., Serratosa, J.M., Treiman, L., Sparkes, R.S., and Parks, M.S.: Linkage studies of juvenile myoclonic epilepsy.  11th International Workshop in Human Gene Mapping, 1991.
  20. Weissbecker, K.A., Delgado-Escueta, A.V., Liu, A. Treiman, L., Serratosa, J.M., Sparkes, R.S.: Sib pair analysis of the linkage of juvenile myoclonic epilepsy to HLA. International Congress of Human genetics., Am. J. Hum. Genet. 49(suppl):A363(2041), 1991.
  21. Liu, A.W., Weissbecker, K.A., Delgado-Escueta, A.V., Serratosa, J.M., Treiman, L., and Sparkes, R.S.: Centromeric markers in chromosome 6p and juvenile myoclonic epilepsy (JME).  Am. Epilepsy Soc. meeting, Philadelphia, PA, Epilepsia 32(S3):100, 1991.
  22. Liu, A.W., Delgado-Escueta, A.V., Weissbecker, K.A., Serratosa, J.M., Treiman, L., Sparkes, R.S., and Greenberg, D.: Juvenile myoclonic epilepsy and reference markers of chromosome 6p.  Am. Epilepsy Soc. meeting, Epilepsia 33(S3):73, 1992.
  23. Weissbecker, K.,: Segregation and linkage analysis of diastolic blood pressure in a large pedigree. Eighth Genetic Analysis Workshop, Pajaros Dunes, CA, Nov. 1992.
  24. Delgado-Escueta, A.V., Liu, A., Weissbecker, K.A., Serratosa, J.M., Medina, M.T., Gee, M, Treiman, L.J., and Sparkes, R.S.: Juvenile myoclonic epilepsy: Is there heterogeneity?  International Workshop on Idiopathic Generalized Epilepsies, Alsace, France, 1993.
  25. Weissbecker, K.A., Berenson, G.S., Wilson, A.F. and Elston, R.C.: Linkage analysis of cardiovascular disease risk factors in three large pedigrees.  American Society of Human Genetics 44th annual meeting, New Orleans, Am. J. Hum. Genet. 53(suppl):A878, 1993.
  26. Weissbecker, K.A., Berenson, G.S., Wilson, A.F., Srinivasan, S.R., and Elston, R.C.: Is there a major gene for the HDL-C/LDL-C ratio? International Genetic Epidemiology Society meeting, New Orleans, Genet. Epidemiology 10:344A, 1993.
  27. Delgado-Escueta, A.V., Liu, A., Serratosa, J.M., Weissbecker, K.A., Medina, M.T., Gee, M, Treiman, L.J., and Sparkes, R.S.: The genetics of epilepsy: Progress in mapping epilepsy genes.  European Society for Pediatric Research meeting, Edinburgh, Scotland, 1993.
  28. Nicolini, H., Mej�a, J., Sanchez-Carmona, M., Weissbecker, K., Camarena, B., and Cruz, C.: Family study of Obessive-Compulsive disorder in a Mexican population. World Congress on Psychiatric Genetics, New Orleans, Psychiatric Genet. 3:184 A169, 1993.
  29. Weissbecker, K.A., Delgado-Escueta, A.V., Medina, M.T., Gee, M., Serratosa, J.M., Maldonado, H., Abad-Herrera, P., Spellman, J., and Sparkes, R.S.: Segregation analysis of Juvenile Myoclonic Epilepsy. American Society of Human Genetics 44th annual meeting, Montreal, Am. J. Hum. Genet. 55(suppl):A974, 1994.
  30. Lacassie, Y., Weissbecker, K.A., Arriaza, M.I., McElveen, C., Bobadilla, O.: Three unusal patients sharing features with the Simpson-Golabi-Behmel syndrome: A clinical dilemma. American Society of Human Genetics 44th annual meeting, Montreal, Quebec, October, Am. J. Hum. Genet. 55(suppl):A1812, 1994.
  31. Weissbecker, K.A., Lacassie, Y., Thomas,T.: To operate or not to operate? - That is the question. A discussion of a patient with a massive, segmental neurofibroma.  National Neurofibromatosis Foundation, 11th Annual Clinical Care Symposium, Los Angeles, CA., March, 1995.
  32. Nicolini, H., Camarena, B., Orozco, b., Cruz, C., Mej�a, J., P�ez, F., De La Fuente, J.R., and Weissbecker, K.A.: Taq1-A2 DRD2 homozygous genotype gives and increased risk to Obsessive-Compulsive Disorder.  Psych. Genet. 5(supplement 1):S107, 1995.
  33. Westling, B., Weissbecker, K.A., Serratosa, J.M., Jara-Prado, A., Alonso, M.E., Cordova, S., Medina, M.T., Gee, M., Iranmanesh, R. and Delgado-Escueta, A.V.: Evidence for linkage of Juvenile myoclonic epilepsy with absence to chromosome 1p., Am. J. Hum. Genet. 59(suppl):A1392, 1996.
  34. Weissbecker, K.A.,  Rice, J., Tynes, S.F., D�Huyvetter, K., Pena, J.M., Snider, L M., Tynes, L.L., and Winstead, D.K.: Reliability of diagnosis: the importance of being honest. World Congress of Psychiatric Genetics meetings, Psych. Genet. 6:173, 1996.
  35. Townsend, M.H., Weissbecker, K.A., Barbee, J. and Winstead, D.: Compusive Behavior in General Anxiety Disorder and Obsessive Compulsive Disorder.  American Psychiatric Association Annual meeting San Diego, May, 1997.
  36. Weissbecker, K.A., Westling, B., Serratosa, J.M., Jara-Prado, A., Alonso, M.E., Cordova, S., Medina, M.T., Gee, M., Iranmanesh, R. and Delgado-Escueta, A.V.: Juvenile myoclonic epilepsy with absence linked to chromosome 1p. Southern Genetic Group meeting, Proceedings of the Greenwood Genetic Center 17:179, 1998.
  37. Weissbecker, K.A., Westling, B., Serratosa, J.M., Jara-Prado, A., Alonso, M.E., Cordova, S., Medina, M.T., Gee, M., Iranmanesh, R. and Delgado-Escueta, A.V.: Juvenile myoclonic epilepsy with absence linked to chromosome 1p. International Genetic Epidemiology Society meeting, Oct., 1997. 
  38. Korczak, J.F., Bergen, A.W., Goldstein, A.M., and Weissbecker, K.A.: Sib-pair linkage analysis of alcoholism: Dichotomous and quantitative measures.  Genetic Analysis Workshop VII, Arcachon, France, Sept., 1998.
  39. Bergen, A.W., Korczak, J.F., Weissbecker, K.A., and Goldstein, A.M.: A genome-wide search for loci contributing to smoking and/or alcoholism.  Genetic Analysis Workshop VII, Arcachon, France, Sept., 1998.
  40. Weissbecker, KA, Pe�a, JM., Snider, LM, Tynes, LL, Tynes, S , Boudoin, C , Green-Leibovitz, MI, and Winstead, DK: Effect Of Co-Morbid Major Depression On Symptoms And Familial Aggregation Of Obsessive Compulsive Disorder. World Congress on Psychiatric Genetics meeting, Molec. Psychiatry 4(S1):S79, 1999.
  41. Weissbecker, K.A., Camerena, B., Rinetti, G., Green-Leibovitz, M., and Nicolini, H.: Obsessive Compulsive Disorder with and with-out tics.  Am J Medical Genetics 105(7):639, 2001.
  42. Weissbecker, K.A., Green-Leibovitz, M, Camerena, B., Rinetti, G., Ezell J., Winstead, D.K., and Nicolini, H.: Complex segregation analysis of Obsessive Compulsive Disorder in Mexican pedigrees. (poster presentation)  Am. J. Hum. Genet. 69(suppl):A1309, 2001.
  43. Weissbecker, K.A. Morava, E.,  Czak�, M.,  K�rteszi, J.,  O'Connor, J.B., and  M�hes K.: Ulnar/fibular ray defect and brachydactyly type E in a family: a possible new autosomal dominant syndrome. Submitted to: American Society of Human Genetics annual meeting.

 

©