Andrew Hollenbach, PhD, is an Assistant Professor of Genetics. He received his BS in Chemistry from the University of Delaware in 1989 and his PhD in Biochemistry from Johns Hopkins University in 1994. Dr. Hollenbach conducted his postdoctoral training with Dr. Gerard Grosveld at St. Jude Children’s Research Hospital in Memphis, Tennessee, and was promoted to a junior faculty position in 2001.  His research focuses on the cell biological mechanisms underlying the formation of the childhood solid muscle tumor alveolar rhabdomyosarcoma (ARMS). ARMS tumors are characterized by the presence of the t(2;13) reciprocal chromosomal translocation that results in the oncogenic fusion protein Pax3-FKHR. Dr. Hollenbach is interested in elucidating how the presence of Pax3-FKHR alters the normal functions and regulation of wild-type Pax3, a transcription factor required for muscle development. Current projects include determining the role of phosphorylation on the biological and biochemical functions of Pax3 and Pax3-FKHR, and examining the regulation of Pax3 and Pax3-FKHR through protein-protein interactions.

PubMed

.

.

. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .